ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020
Optogenetic reactivation of prefrontal social neural ensembles mimics social buffering of fear.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Trans-Vitisin B Targets Neuroinflammation, Oxidative Stress, and Tau Pathology to Improve Behavioral Outcomes in a Mouse Model of Parkinson's Disease.Antioxidants (Basel, Switzerland) · 2026Article
- Distinct projections of PVN oxytocin neurons regulate the divergent defensive behaviors in response to social threat.Science advances · 2026Article
- Social touch-like tactile stimulation alleviates stress-induced anxiety-like behavior by enhancing the oxytocin level in the prefrontal cortex.Neurobiology of stress · 2026Article
- State-dependent reward circuit modulation gates social buffering of stress.Research square · 2026Article
- Neural Mechanisms of Social Homeostasis: Dynamic Range Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Protocol for the generation of single-nuclei RNA-seq libraries and quantification of heterogeneous cell types activated during social interaction.STAR protocols · 2024Article
- Pharmacological stimulation of infralimbic cortex after fear conditioning facilitates subsequent fear extinction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Distinct transcriptional programs define a heterogeneous neuronal ensemble for social interaction.iScience · 2024Article
- Glucocorticoid response to naturalistic interactions between children and dogs.Hormones and behavior · 2024Article
- Pharmacological stimulation of infralimbic cortex after fear conditioning facilitates subsequent fear extinction.bioRxiv : the preprint server for biology · 2024Article
- Social buffering in rats reduces fear by oxytocin triggering sustained changes in central amygdala neuronal activity.Nature communications · 2024Article
- Distinct transcriptional programs define a heterogeneous neuronal ensemble for social interaction.bioRxiv : the preprint server for biology · 2023Article
- Article
- Sex differences in social buffering and social contagion of alarm responses in zebrafish.Animal cognition · 2023Article
- Poststress social isolation exerts anxiolytic effects by activating the ventral dentate gyrus.Neurobiology of stress · 2023Article
- Infant pain vs. pain with parental suppression: Immediate and enduring impact on brain, pain and affect.PloS one · 2023Article
- Article
- Social buffering of the stress response: insights from fishes.Biology letters · 2022Review
- Social Buffering as a Tool for Improving Rodent Welfare.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Social buffering occurs when the presence of a companion attenuates the physiological and/or behavioral effects of a stressful or fear-provoking event. It represents a way in which social interactions can immediately and potently modulate behavior. As such, social buffering is one mechanism by which strong social support increases resilience to mental illness. Although the behavioral and neuroendocrine impacts of social buffering are well studied in multiple species, including humans, the neuronal underpinnings of this behavioral phenomenon remain largely unexplored. Previous work has shown that the infralimbic prefrontal cortex (IL-PFC) is important for processing social information and, in separate studies, for modulating fear and anxiety. Thus, we hypothesized that socially active cells within the IL-PFC may integrate social information to modulate fear responsivity. To test this hypothesis, we employed social buffering paradigms in male and female mice. Similar to prior studies in rats, we found that the presence of a cagemate reduced freezing in fear- and anxiety-provoking contexts. In accordance with previous work, we demonstrated that interaction with a novel or familiar conspecific induces activity in the IL-PFC as evidenced by increased immediate early gene (IEG) expression. We then utilized an activity-dependent tagging murine line, the ArcCreER
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.