Evidence map›Paper›PMID 32035126›Full record

SynthesisProgress in cardiovascular diseases

Prevention of cardiovascular disease among people living with HIV in sub-Saharan Africa.

Samson Okello, Abdallah Amir, Gerald S Bloomfield, Katie Kentoffio, Henry M Lugobe, Zahra Reynolds, Itai M Magodoro, Crystal M North, Emmy Okello, Robert Peck and 1 more

Abstract readSystematic Review
In one paragraph

Synthesis in Progress in cardiovascular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Samson OkelloDepartment of Internal Medicine, Mbarara University of Science and Technology, Mbarara, Uganda; Lown Scholars Program, Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Medicine, University of Virginia Health Systems, Charlottesville, VA, USA. Electronic address: okello.samson@must.ac.ug.
Abdallah AmirDepartment of Internal Medicine, Mbarara University of Science and Technology, Mbarara, Uganda; Department of Neurology, Mayo Clinic, Phoenix/Scottsdale, AZ, USA.
Gerald S BloomfieldDuke Clinical Research Institute, Durham, NC, USA; Duke Global Health Institute, Durham, NC, USA; Duke University Medical Center, Durham, NC, USA.
Katie KentoffioDepartment of Cardiology, University of California San Francisco, San Francisco, CA, USA.
Henry M LugobeDepartment of Obstetrics and Gynecology, Mbarara University of Science and Technology, Mbarara, Uganda.
Zahra ReynoldsDepartment of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Itai M MagodoroDepartments of Medicine & Diagnostic Radiology, McGill University Health Center, Montreal, QC, Canada; Division of Cardiology, University of Cape Town, Cape Town, South Africa.
Crystal M NorthDepartment of Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Emmy OkelloUganda Heart Institute, Kampala, Uganda.
Robert PeckThe Center for Global Health, Weill Cornell Medical Center for Global Health, New York, USA; Department of Internal Medicine, Weill Bugando School of Medicine, Mwanza, Tanzania.
Mark J SiednerDepartment of Internal Medicine, Mbarara University of Science and Technology, Mbarara, Uganda; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

Funding

Quality of Life and Aging with HIV in Rural UgandaR01AG059504 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI SIEDNER, MARK J · 2019 to 2023
$3.4M
Resistance testing versus adherence support for management of patients with virologic failure on first-line antiretroviral therapy in sub-Saharan Africa: An open-label randomized controlled trialR01AI124718 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MUYINDIKE, WINNIE, SIEDNER, MARK J · 2016 to 2020
$3.0M
Epidemiology of coronary artery disease among people with HIV in rural sub-Saharan AfricaR01HL141053 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SIEDNER, MARK J · 2018 to 2021
$3.0M
Hypertension in HIV-Infected Tanzanians: Time Course and PathogenesisK01TW010281 · FIC · WEILL MEDICAL COLL OF CORNELL UNIV · PI PECK, ROBERT N · 2015 to 2019
$689k
Polycyclic aromatic hydrocarbons exposure and dietary risk of Esophageal squamous cell carcinoma in UgandaK43TW010715 · FIC · MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY · PI OKELLO, SAMSON · 2017 to 2021
$456k
FIC NIH HHS K01 TW010281FIC NIH HHS K43 TW010715NHLBI NIH HHS R01 HL141053NIAID NIH HHS R01 AI124718NIA NIH HHS R01 AG059504
6 · The paper itself

Abstract

As longevity has increased for people living with HIV (PLWH) in the United States and Europe, there has been a concomitant increase in the prevalence of cardiovascular disease (CVD) risk factors and morbidity in this population. Whereas the availability of HIV antiretroviral therapy has resulted in dramatic increases in life expectancy in sub-Saharan Africa (SSA), where over two thirds of PLWH reside, if and how these trends impact the epidemiology of CVD is less clear. In this review, we describe the current state of the science on how both HIV and its treatment impact CVD risk factors and outcomes among PLWH in sub-Saharan Africa, including regional factors (unique to SSA) likely to differentiate these relationships from the global North. We then outline how current regional guidelines address CVD prevention among PLWH and which clinical and structural interventions are best poised to confront the co-epidemics of HIV and CVD in the region. We conclude with a discussion of key research gaps that need to be addressed to optimally develop an actionable public health response.

Indexed as

HIV Long-Term SurvivorsPreventive Health ServicesAfrica South of the SaharaAnti-HIV AgentsCardiovascular DiseasesHealthcare DisparitiesHealth StatusHealth Status DisparitiesHIV InfectionsHumansLife ExpectancyPrognosisProtective FactorsRisk AssessmentRisk FactorsViral LoadAnti-HIV AgentsCardiovascular diseaseCardiovascular risk factorsPeople living with HIVSub-Saharan Africa

Identifiers

PMID32035126
PMCPMC7237320

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.