Evidence map›Paper›PMID 32035093›Full record

ArticleThe Journal of investigative dermatology2020

Lgr4 Deletion Delays the Hair Cycle and Inhibits the Activation of Hair Follicle Stem Cells.

Xiaolin Ren, Weili Xia, Peng Xu, Hongyang Shen, Xing Dai, Mingyao Liu, Yuling Shi, Xiyun Ye, Yongyan Dang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. mTORC1 regulates the proliferation of SOX9Histochemistry and cell biology · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Ontogeny of Skin Stem Cells and Molecular Underpinnings.Current issues in molecular biology · 2024
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Functional hair follicle regeneration: an updated review.Signal transduction and targeted therapy · 2021
    Review
  19. Review
  20. Development and Maintenance of Epidermal Stem Cells in Skin Adnexa.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Xiaolin RenShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Weili XiaShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Peng XuDepartment of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Hongyang ShenShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Xing DaiDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, California, USA.
Mingyao LiuShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Yuling ShiDepartment of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: shiyuling1973@tongji.edu.cn.
Xiyun YeShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. Electronic address: xyye@bio.ecnu.edu.cn.
Yongyan DangShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. Electronic address: yydang@bio.ecnu.edu.cn.
East China Normal University · CNTongji University · CNUniversity of California, Irvine · US

Funding

Multiscale Models of Wound Cell Plasticity for RegenerationU01AR073159 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAI, XING, NIE, QING · 2018 to 2022
$3.5M
Control of epithelial plasticity and differentiation in hair follicle stem/progenitor cellsR01AR068074 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAI, XING · 2015 to 2019
$1.7M
NIAMS NIH HHS R01 AR068074NIAMS NIH HHS U01 AR073159
6 · The paper itself

Abstract

It is known that LGR4 plays an important role in hair follicle (HF) development, but the impact of LGR4 on the hair cycle is still unclear. In this study, we have found that K14-Cre-mediated skin epithelia-specific deletion of Lgr4 results in delayed anagen entry during the physiological hair cycle and compromised HF regeneration upon transplantation. We show that, although Lgr4 deletion does not appear to affect the number of quiescent HF stem cells, it leads to reduced numbers of LGR5

Indexed as

AcetatesAdult Stem CellsAnimalsBenzopyransBone Morphogenetic ProteinsCell ProliferationFemaleHair FollicleMaleMiceMice, KnockoutModels, AnimalProto-Oncogene Proteins c-aktReceptors, G-Protein-CoupledRegenerationSkinAcetatesAkt1 protein, mouseAKT activator SC79BenzopyransBone Morphogenetic ProteinsLGR4 protein, mousemTOR protein, mouseProto-Oncogene Proteins c-aktReceptors, G-Protein-CoupledTOR Serine-Threonine Kinases

Identifiers

PMID32035093
PMCPMC8507220
OpenAlexW3004528451

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.