Evidence map›Paper›PMID 32035061›Full record

ArticleThe American journal of pathology2020

CXCL11-CXCR3 Axis Mediates Tumor Lymphatic Cross Talk and Inflammation-Induced Tumor, Promoting Pathways in Head and Neck Cancers.

Subhashree Kumaravel, Sumeet Singh, Sukanya Roy, Lavanya Venkatasamy, Tori K White, Samiran Sinha, Shannon S Glaser, Stephen H Safe, Sanjukta Chakraborty

Open access · hybridAbstract read
In one paragraph

Article in The American journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Lymphatic transport in anti-tumor immunity and metastasis.The Journal of experimental medicine · 2025
    Review
  8. Article
  9. Stearoyl-CoA desaturase in CD4Cell & bioscience · 2024
    Article
  10. Chemokine Receptor-4 Targeted PET/CT Imaging withDiagnostics (Basel, Switzerland) · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Subhashree KumaravelDepartment of Medical Physiology, Texas A&M Health Science Center College of Medicine, Bryan, Texas.
Sumeet SinghDepartment of Medical Physiology, Texas A&M Health Science Center College of Medicine, Bryan, Texas.
Sukanya RoyDepartment of Medical Physiology, Texas A&M Health Science Center College of Medicine, Bryan, Texas.
Lavanya VenkatasamyDepartment of Medical Physiology, Texas A&M Health Science Center College of Medicine, Bryan, Texas.
Tori K WhiteDepartment of Medical Physiology, Texas A&M Health Science Center College of Medicine, Bryan, Texas.
Samiran SinhaDepartment of Statistics, Texas A&M University, College Station, Texas.
Shannon S GlaserDepartment of Medical Physiology, Texas A&M Health Science Center College of Medicine, Bryan, Texas.
Stephen H SafeDepartment Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas.
Sanjukta ChakrabortyDepartment of Medical Physiology, Texas A&M Health Science Center College of Medicine, Bryan, Texas. Electronic address: schakraborty@tamu.edu.
Texas A&M Health Science Center · USTexas A&M University · US

Funding

TARGETED GENOMICS FACILITY COREP30ES023512 · NIEHS · TEXAS A&M AGRILIFE RESEARCH · PI THREADGILL, DAVID W. · 2014 to 2017
$3.3M
Neuroendocrine Regulation of Biliary Growth and FibrosisR01DK110035 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2017 to 2020
$1.2M
NIDDK NIH HHS R01 DK110035NIEHS NIH HHS P30 ES023512
6 · The paper itself

Abstract

Tumor metastasis to the draining lymph nodes is critical in patient prognosis and is tightly regulated by molecular interactions mediated by lymphatic endothelial cells (LECs). The underlying mechanisms remain undefined in the head and neck squamous cell carcinomas (HNSCCs). Using HNSCC cells and LECs we determined the mechanisms mediating tumor-lymphatic cross talk. The effects of a pentacyclic triterpenoid, methyl 2-trifluoromethyl-3,11-dioxoolean-1,12-dien-30-oate (CF

Indexed as

Antineoplastic AgentsChemokine CXCL11Endothelial CellsEpithelial-Mesenchymal TransitionHead and Neck NeoplasmsHumansInflammationLymphatic MetastasisPrognosisReceptors, CXCR3Signal TransductionSquamous Cell Carcinoma of Head and NeckTriterpenesTumor Cells, CulturedAntineoplastic AgentsChemokine CXCL11CXCL11 protein, humanCXCR3 protein, humanReceptors, CXCR3Triterpenes

Identifiers

PMID32035061
PMCPMC7180517
OpenAlexW3004929359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.