Evidence map›Paper›PMID 32035060›Full record

ArticleThe American journal of pathology2020

mTORC2 Signaling Is Necessary for Timely Liver Regeneration after Partial Hepatectomy.

Meng Xu, Haichuan Wang, Jingxiao Wang, Deviana Burhan, Runze Shang, Pan Wang, Yi Zhou, Rong Li, Bingyong Liang, Katja Evert and 9 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 4 countries.

Meng XuDepartment of General Surgery, The Second Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, PR China; Department of Bioengineering and Therapeutic Sciences, Liver Center, University of California, San Francisco, California.
Haichuan WangDepartment of Liver Surgery, Liver Transplantation Division, West China Hospital, Sichuan University, Chengdu, PR China; Department of Bioengineering and Therapeutic Sciences, Liver Center, University of California, San Francisco, California; Laboratory of Liver Surgery, West China Hospital, Sichuan University, Chengdu, PR China; Department of General Surgery, The Second Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, PR China.
Jingxiao WangDepartment of Bioengineering and Therapeutic Sciences, Liver Center, University of California, San Francisco, California; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, PR China.
Deviana BurhanDepartment of Medicine, Liver Center, University of California, San Francisco, California.
Runze ShangDepartment of Bioengineering and Therapeutic Sciences, Liver Center, University of California, San Francisco, California; Department of Hepatobiliary Surgery, Xijing Hospital, Air Force Military Medical University, Xi'an, PR China.
Pan WangDepartment of Bioengineering and Therapeutic Sciences, Liver Center, University of California, San Francisco, California; Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, Beijing, PR China.
Yi ZhouDepartment of Bioengineering and Therapeutic Sciences, Liver Center, University of California, San Francisco, California; Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, PR China.
Rong LiDepartment of Anesthesiology, The Second Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, PR China.
Bingyong LiangDepartment of Bioengineering and Therapeutic Sciences, Liver Center, University of California, San Francisco, California; Hepatic Surgery Center, Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Katja EvertInstitute of Pathology, University of Regensburg, Regensburg, Germany.
Kirsten UtpatelInstitute of Pathology, University of Regensburg, Regensburg, Germany.
Zhong XuDepartment of Gastroenterology, Guizhou Provincial People's Hospital, Medical College of Guizhou University, Guiyang, PR China.
Xinhua SongDepartment of Bioengineering and Therapeutic Sciences, Liver Center, University of California, San Francisco, California.
Li CheDepartment of Bioengineering and Therapeutic Sciences, Liver Center, University of California, San Francisco, California.
Diego F CalvisiInstitute of Pathology, University of Regensburg, Regensburg, Germany.
Bruce WangDepartment of Medicine, Liver Center, University of California, San Francisco, California.
Xi ChenDepartment of General Surgery, The Second Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, PR China.
Yong ZengDepartment of Liver Surgery, Liver Transplantation Division, West China Hospital, Sichuan University, Chengdu, PR China; Laboratory of Liver Surgery, West China Hospital, Sichuan University, Chengdu, PR China. Electronic address: zengyong@medmail.com.cn.
Xin ChenDepartment of Bioengineering and Therapeutic Sciences, Liver Center, University of California, San Francisco, California. Electronic address: xin.chen@ucsf.edu.
University of California, San Francisco · USUniversity of Regensburg · DEBeijing University of Chinese Medicine · CNGuizhou University · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CNTongji University · CN

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Y. Chen · 1986 to 2026
$30.7M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8M
Molecular Genetics of Liver CancersR01CA136606 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHEN, XIN · 2009 to 2016
$2.6M
Yap and beta-catenin interactions in liver: Implications in PathophysiologyR01CA204586 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, XIN, MONGA, SATDARSHAN SINGH · 2016 to 2020
$2.1M
Wnt signaling in hepatocyte homeostasisK08DK101603 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WANG, BRUCE MAO ZHENG · 2015 to 2019
$829k
NCI NIH HHS R01 CA136606NCI NIH HHS R01 CA204586NIDDK NIH HHS K08 DK101603NIDDK NIH HHS P30 DK026743NIDDK NIH HHS P30 DK063720
6 · The paper itself

Abstract

Liver regeneration is a fundamental biological process required for sustaining body homeostasis and restoring liver function after injury. Emerging evidence demonstrates that cytokines, growth factors, and multiple signaling pathways contribute to liver regeneration. Mammalian target of rapamycin complex 2 (mTORC2) regulates cell metabolism, proliferation and survival. The major substrates for mTORC2 are the AGC family members of kinases, including AKT, SGK, and PKC-α. We investigated the functional roles of mTORC2 during liver regeneration. Partial hepatectomy (PHx) was performed in liver-specific Rictor (the pivotal unit of mTORC2 complex) knockout (Rictor

Indexed as

Cell ProliferationHepatectomyLiver RegenerationAnimalsCell Cycle CheckpointsFemaleLipidsLiverMaleMechanistic Target of Rapamycin Complex 2MiceMice, Inbred C57BLMice, KnockoutPhosphorylationRapamycin-Insensitive Companion of mTOR ProteinSignal TransductionLipidsMechanistic Target of Rapamycin Complex 2Rapamycin-Insensitive Companion of mTOR Proteinrictor protein, mouse

Identifiers

PMID32035060
PMCPMC7180798
OpenAlexW3004883499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.