ArticleExperimental physiology2020
Splenocyte transfer exacerbates salt-sensitive hypertension in rats.
Article in Experimental physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 22 citations in OpenAlex.
- Inhibition of ROCK2 via KD025/Belumosudil Alleviates Hypertensive End-Organ Damage.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Exacerbation of Dahl SS Hypertension and Renal Damage by NOX2 in CD4+ T Cells.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Intact NOX2 in T Cells Mediates Pregnancy-Induced Renal Damage in Dahl SS Rats.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Sex-Dependency of T Cell-Induced Salt-Sensitive Hypertension and Kidney Damage.Hypertension (Dallas, Tex. : 1979) · 2024Article
- T-cells regulate albuminuria but not hypertension, renal histology, or the medullary transcriptome in the Dahl SSCD247American journal of physiology. Renal physiology · 2024Article
- Dietary Sodium and Human Health.Nutrients · 2023Article
- Functional NADPH oxidase 2 in T cells amplifies salt-sensitive hypertension and associated renal damage.American journal of physiology. Renal physiology · 2023Article
- Chronic treatment with IL-25 increases renal M2 macrophages and reduces renal injury in obese Dahl salt-sensitive rats during the prepubescent stage.American journal of physiology. Renal physiology · 2023Article
- Impact of bedding on Dahl salt-sensitive hypertension and renal damage.American journal of physiology. Renal physiology · 2022Article
- Gut-Immune-Kidney Axis: Influence of Dietary Protein in Salt-Sensitive Hypertension.Hypertension (Dallas, Tex. : 1979) · 2022Review
- The SSAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Splenocyte transfer from hypertensive donors eliminates premenopausal female protection from ANG II-induced hypertension.American journal of physiology. Renal physiology · 2022Article
- Coupling of phagocytic NADPH oxidase activity and mitochondrial superoxide production.Frontiers in cardiovascular medicine · 2022Article
- T Cell Immunometabolism and Redox Signaling in Hypertension.Current hypertension reports · 2021Review
- Article
- Dietary protein source contributes to the risk of developing maternal syndrome in the Dahl salt-sensitive rat.Pregnancy hypertension · 2021Article
- Contribution of Th17 cells to tissue injury in hypertension.Current opinion in nephrology and hypertension · 2021Review
- Amplification of Salt-Sensitive Hypertension and Kidney Damage by Immune Mechanisms.American journal of hypertension · 2021Review
- The Role of Neutrophils in Hypertension.International journal of molecular sciences · 2020Review
- Biological Context Linking Hypertension and Higher Risk for COVID-19 Severity.Frontiers in physiology · 2020Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
NEW
findingsWhat is the central question of this study? Recruitment of immune cells to the kidney potentiates hypertensive pathology, but more refined methods are needed to assess these cells functionally. Adoptive transfer studies of immune cells have been limited in rat models and especially in the study of salt-sensitive hypertension. We tested the hypothesis that splenocyte transfer into T-cell-deficient rats is sufficient to exacerbate salt-sensitive hypertension. What is the main finding and its importance? We demonstrate that transfer of splenocytes into T-cell-deficient animals exacerbates salt-sensitive hypertension, and an enrichment in the CD4 ABSTRACT: Increasing evidence of immune system activation during the progression of hypertension and renal injury has led to a need for new methods to study individual cell types. Transfer of immune cells serves as a powerful tool to isolate effects of specific subsets. Transfer studies in Rag1
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.