ReviewBritish journal of clinical pharmacology2020
How the EMERGE guideline on medication adherence can improve the quality of clinical trials.
Review in British journal of clinical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect ofNutrients · 2021Pooled it
- Medication Adherence Behavior Assessed Using a Digital Bottle Cap: Retrospective Cohort Study.Journal of medical Internet research · 2026Trial
- Study design of the InTakeCare trial: a digital health solution to monitor and improve medication adherence in hypertensive patients.European heart journal. Digital health · 2026Article
- Informing Inclusive Engagement in Clinical Research: Insights From a Long-Standing Community-Based Wellness and Prescription Produce Program.Clinical and translational science · 2025Article
- Observational
- Under the radar-frequency, timing, duration, and trajectory of lower-grade adverse events in clinical trials of anti-cancer therapies.The oncologist · 2025Article
- Risk of bias tools for medication adherence research: RoBIAS and RoBOAS.British journal of clinical pharmacology · 2025Article
- New integrations in patient care: the role of the pharmacist between couselling and medication adherence.Journal of preventive medicine and hygiene · 2025Article
- Medication non-adherence: reflecting on two decades since WHO adherence report and setting goals for the next twenty years.Frontiers in pharmacology · 2024Article
- The Importance of Assessing Drug Exposure and Medication Adherence in Evaluating Investigational Medications: Ensuring Validity and Reliability of Clinical Trial Results.Pharmaceutical medicine · 2024Article
- Pairwise comparisons of three medication adherence outcomes in adolescents who use alcohol.Alcohol, clinical & experimental research · 2023Article
- Medication adherence reporting in pivotal clinical trials: overview of oral oncological drugs.European journal of hospital pharmacy : science and practice · 2023Article
- Patient Preferences and Their Influence on Chronic Hepatitis B-A Review.Patient preference and adherence · 2023Review
- Medication Adherence Measurement Methods in Registration Trials Supporting the Approval of New Medicines: A Cross-Sectional Analysis of Centralized Procedures in the European Union 2010-2020.Clinical pharmacology and therapeutics · 2022Article
- Comparison of different methods to assess tacrolimus concentration intra-patient variability as potential marker of medication non-adherence.Frontiers in pharmacology · 2022Article
- Real-world Evidence for Adherence and Persistence with Atorvastatin Therapy.Cardiology and therapy · 2021Review
- A Novel Digital Pill System for Medication Adherence Measurement and Reporting: Usability Validation Study.JMIR human factors · 2021Article
- Patient and healthcare provider perspectives on adherence with antihypertensive medications: an exploratory qualitative study in Tanzania.BMC health services research · 2021Article
- Digitally Enabled, Patient-Centric Clinical Trials: Shifting the Drug Development Paradigm.Clinical and translational science · 2021Review
- Electronic Monitoring Feedback for Improving Medication Adherence and Clinical Outcomes in Early Rheumatoid Arthritis: A Randomized Clinical Trial.Patient preference and adherence · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medication adherence in drug trials is suboptimal, affecting the quality of these studies and adding significant costs. Nonadherence in this setting can lead to null findings, unduly large sample sizes and the need for dose modification after a drug has been approved. Despite these drawbacks, adherence behaviours are not consistently measured, analysed or reported appropriately in trial settings. The ESPACOMP Medication Adherence Reporting Guideline (EMERGE) offers a solution by facilitating a sound protocol design that takes this crucial factor into account. This article summarises key evidence on traditional and newer measurements of adherence, discusses implementation in clinical trial settings and makes recommendations about the analysis and interpretation of adherence data. Given the potential benefits of this approach, the authors call on regulators and the pharmaceutical industry to endorse the EMERGE guideline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.