Evidence map›Paper›PMID 32034695›Full record

ArticleNeurotoxicity research2020

Nickel-Induced Developmental Neurotoxicity in C. elegans Includes Cholinergic, Dopaminergic and GABAergic Degeneration, Altered Behaviour, and Increased SKN-1 Activity.

Omamuyovwi M Ijomone, Mahfuzur R Miah, Grace T Akingbade, Hana Bucinca, Michael Aschner

Abstract read
In one paragraph

Article in Neurotoxicity research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 61 citations in OpenAlex.

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  14. Occupational multimorbidity in the nickel industry workers.International journal of circumpolar health · 2023
    Article
  15. Article
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  18. Review
  19. Axenic Culture ofInternational journal of molecular sciences · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Omamuyovwi M IjomoneDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, New York, NY, USA. ijomoneom@futa.edu.ng.ORCID https://orcid.org/0000-0002-0933-8409
Mahfuzur R MiahDepartment of Neuroscience, Albert Einstein College of Medicine, New York, NY, USA.
Grace T AkingbadeThe Neuro-Lab, Department of Human Anatomy, School of Health and Health Technology, Federal University of Technology, Akure, Nigeria.
Hana BucincaDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, New York, NY, USA.
Michael AschnerDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, New York, NY, USA. michael.aschner@einstein.yu.edu.
Albert Einstein College of Medicine · USFederal University of Technology · NG

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2M
Mechanisms of Manganese NeurotoxicityR01ES010563 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 2001 to 2026
$11.9M
Mechanisms of Methylmercury Induced Neuron ToxicityR01ES007331 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 1996 to 2026
$10.6M
Genetic Modulation of MeHg-Induced Oxidative Stress in the Developing BrainR01ES020852 · NIEHS · VANDERBILT UNIVERSITY · PI ASCHNER, MICHAEL · 2012 to 2016
$1.8M
International Brain Research Organization IBRO-ISN RF2017International Society for Neurochemistry IBRO-ISN RF2017NCI NIH HHS P30 CA013330NIEHS NIH HHS R01 ES007331NIEHS NIH HHS R01 ES010563NIEHS NIH HHS R01 ES020852NIH HHS R01 ES020852NIH HHS R01 ES07331NIMH NIH HHS R01 ES10563
6 · The paper itself

Abstract

Nickel (Ni) is a ubiquitous metal in the environment with increasing industrial application. While environmental and occupational exposure to Ni compounds has been known to result in toxicities to several organs, including the liver, kidney, lungs, skin and gonads, neurotoxic effects have not been extensively investigated. In this present study, we investigated specific neuronal susceptibility in a C. elegans model of acute Ni neurotoxicity. Wild-type worms and worms expressing green fluorescent protein (GFP) in either cholinergic, dopaminergic or GABAergic neurons were treated with NiCl

Indexed as

AnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsCholinergic NeuronsDNA-Binding ProteinsDopaminergic NeuronsDose-Response Relationship, DrugGABAergic NeuronsGreen Fluorescent ProteinsLocomotionNerve DegenerationNickelTranscription FactorsCaenorhabditis elegans ProteinsDNA-Binding ProteinsGreen Fluorescent ProteinsNickelnickel chlorideskn-1 protein, C elegansTranscription FactorsBehaviourC. elegansNeurodegenerationNickelOxidative stress

Identifiers

PMID32034695
PMCPMC13544494
OpenAlexW3004775015

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.