Evidence map›Paper›PMID 32034694›Full record

ArticleNeurotoxicity research2020

Serum Uric Acid Levels and Risk of Intracranial Atherosclerotic Stenosis: A Cross-Sectional Study.

Lin Li, Jun-Xia Zhu, Xiao-He Hou, Ya-Hui Ma, Wei Xu, Chen-Chen Tan, Fu-Rong Sun, Hong-Qi Li, Qiang Dong, Lan Tan and 1 more

Abstract read
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In one paragraph

Article in Neurotoxicity research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Lin LiDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China.
Jun-Xia ZhuDepartment of Prevention and Health Protection, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Xiao-He HouDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China.
Ya-Hui MaDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China.
Wei XuDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China.
Chen-Chen TanDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China.
Fu-Rong SunDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China.
Hong-Qi LiDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12th Wulumuqi Zhong Road, Shanghai, 200040, China.
Qiang DongDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12th Wulumuqi Zhong Road, Shanghai, 200040, China. dong_qiang@fudan.edu.cn.
Lan TanDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China. dr.tanlan@163.com.
Jin-Tai YuDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12th Wulumuqi Zhong Road, Shanghai, 200040, China. jintai_yu@fudan.edu.cn.
Qingdao Municipal Hospital · CNQingdao University · CNFudan University · CNHuashan Hospital · CN

Funding

Shanghai Municipal Science and Technology Major Project No.2018SHZDZX01Taishan Scholars Program of Shandong Province ts201511109Taishan Scholars Program of Shandong Province tsqn20161079
6 · The paper itself

Abstract

Elevated serum uric acid (SUA) has been reported to be associated with an increased risk of cardiovascular diseases, but the role of SUA in intracranial atherosclerosis remains unclear. To investigate the association between SUA and intracranial atherosclerotic stenosis (ICAS), we evaluated 1522 subjects (305 with ICAS, 1217 without ICAS) with magnetic resonance angiography (MRA). Subjects were classified into ten groups according to the deciles of the SUA level. The rate of ICAS reached a minimum in the seventh decile (6.0-6.3 mg/dL; reference group). After adjusting for confounding factors, multivariate logistic regression analysis demonstrated that both low SUA level (≤ 3.8 mg/dL; OR, 2.34; 95% CI, 1.29-4.39; p = 0.006) and high SUA level (≥ 7.8 mg/dL; OR, 2.10; 95% CI, 1.15-3.92; p = 0.017) conferred greater risk for ICAS. In multivariable analysis with a quadratic model which used SUA as a continuous variable, a U-shaped association between SUA and the rate of ICAS was confirmed (α > 0; p < 0.001). The estimated SUA level associated with the lowest rate of ICAS was 6.2 mg/dL. In conclusion, our findings suggest a U-shaped association between ICAS and SUA.

Indexed as

AgedAged, 80 and overBiomarkersCohort StudiesCross-Sectional StudiesFemaleHumansIntracranial ArteriosclerosisMagnetic Resonance AngiographyMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesRisk FactorsUric AcidBiomarkersUric AcidIntracranial atherosclerotic stenosisMagnetic resonance angiographySerum uric acidU-shaped association

Identifiers

PMID32034694
OpenAlexW3004598537

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.