ReviewClinical reviews in allergy & immunology2020
Using Baseline and Peak Serum Tryptase Levels to Diagnose Anaphylaxis: a Review.
Review in Clinical reviews in allergy & immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Tranexamic acid-induced anaphylaxis: a systematic review.European journal of clinical pharmacology · 2025Pooled it
- Remimazolam-Induced Anaphylaxis and Cardiovascular Collapse: A Narrative Systematic Review of Eleven Cases.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Unusual Causes of Food-Induced Anaphylaxis - A Review.Indian dermatology online journal · 2026Article
- Diagnostic Performance of Biomarkers for Perioperative Hypersensitivity Reactions in Adults: A Systematic Review and Meta-Analysis on Tryptase and Histamine Dosing.Diagnostics (Basel, Switzerland) · 2026Review
- Overview of allergic disease: Anaphylaxis - WAO White Book on Allergy 2026 - 2.11.The World Allergy Organization journal · 2026Review
- In vitro diagnostics of drug hypersensitivity reactions.Allergologie select · 2026Review
- IgE and non-IgE-mediated pathways in anaphylaxis.Seminars in immunopathology · 2025Review
- Pediatric anaphylaxis in the emergency department: Performances of dynamic tryptase measurement.The journal of allergy and clinical immunology. Global · 2025Article
- Anaphylactic reaction to tranexamic acid infusion in a six-year-old child: a case report.International journal of emergency medicine · 2024Article
- Cardiac Arrest Due to Perioperative Anaphylactic Shock Induced by Re-Exposure to Propofol: A Case Report.Journal of clinical medicine · 2024Article
- Identifying patients at risk of anaphylaxis.The World Allergy Organization journal · 2024Review
- Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial.Nature communications · 2023Article
- Clinical Characteristics of Anaphylaxis in Children Aged 0-16 Years in Xi'an, China.International archives of allergy and immunology · 2023Article
- Anaphylaxis after consumption of wasp larvae in Reunion Island: a case report.Frontiers in allergy · 2023Article
- An interdisciplinary approach to characterize peanut-allergic patients-First data from the FOOD@ consortium.Clinical and translational allergy · 2022Article
- Fish Roe-Induced Anaphylaxis in Italy: A Pediatric Case Report.Pediatric reports · 2022Article
- Serological profiling reveals hsa-miR-451a as a possible biomarker of anaphylaxis.JCI insight · 2022Article
- Estimating the within-subject (CVImmunity, inflammation and disease · 2022Review
- Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines.Nature nanotechnology · 2022Review
- New Biomarkers in Anaphylaxis (Beyond Tryptase).Current treatment options in allergy · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diagnosis of anaphylaxis relies on a suggestive clinical history after exposure to a potential triggering factor. Serum tryptase concentrations increase on degranulation of mast cells and therefore serum tryptase levels are measured to diagnose anaphylaxis. There is no standardized method for assessing total serum mast cell tryptase (MCT) in anaphylaxis. The Working Conference in 2010 proposed a consensus equation (peak MCT should be > 1.2x baseline tryptase + 2 ng/L) to diagnose acute mast cell activation (aMCA). Our objective was to narratively review the literature since the Working Conference in 2010, examining the use of the consensus equation and other equations comparing baseline and peak serum tryptase during anaphylaxis. Computerized bibliographic searches of PUBMED and EMBASE were supplemented with a manual search of reference lists. English-language studies were included. Eleven studies met our inclusion criteria with a total of 4551 participants. However, only four studies with 653 participants used the consensus equation. The other seven studies used other methods to compare peak and baseline serum tryptase concentrations. Measuring serum tryptase levels is valuable in the diagnosis of anaphylaxis but is unable to detect all anaphylactic reactions. Based on our current literature review, the consensus equation is underused in the diagnosis of anaphylaxis. There is also a need for exploration of other biomarkers which could be used in parallel to peak and baseline serum tryptase measurements for further diagnostic certainty. Serum tryptase is the most studied biomarker in anaphylaxis but is still far from being the ideal biomarker for this. There is a need to identify new potential useful biomarkers. Serum tryptase levels are valuable in the diagnosis of anaphylaxis, but are unable to detect all anaphylactic reactions. Additionally serial tryptase measurements are laborious in daily clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.