ArticleCerebellum (London, England)2020
Locomotor Adaptation Is Associated with Microstructural Properties of the Inferior Cerebellar Peduncle.
Article in Cerebellum (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Transcutaneous electrical nerve stimulation enhances locomotor adaptation savings in people with multiple sclerosis.Brain communications · 2025Trial
- Locomotor adaptation on a split-belt treadmill: mechanisms, modulation, and clinical utility.Journal of neurophysiology · 2026Review
- A model of the cerebellum generates gait adaptations in a reflex-based neuromusculoskeletal model during split-belt walking.Journal of neuroengineering and rehabilitation · 2025Article
- A model of the cerebellum generates gait adaptations in a reflex-based neuromusculoskeletal model during split-belt walking.bioRxiv : the preprint server for biology · 2025Article
- Propulsive Force Modulation Drives Split-Belt Treadmill Adaptation in People with Multiple Sclerosis.Sensors (Basel, Switzerland) · 2024Article
- The Contributions of the Cerebellar Peduncles and the Frontal Aslant Tract in Mediating Speech Fluency.Neurobiology of language (Cambridge, Mass.) · 2024Article
- Causal relationship between multiparameter brain MRI phenotypes and age: evidence from Mendelian randomization.Brain communications · 2024Article
- Microstructural Properties of the Cerebellar Peduncles in Children With Developmental Language Disorder.Neurobiology of language (Cambridge, Mass.) · 2024Article
- Structural and functional changes of the cerebellum in temporal lobe epilepsy.Frontiers in neurology · 2023Article
- Organization of sensorimotor activity in anterior cruciate ligament reconstructed individuals: an fMRI conjunction analysis.Frontiers in human neuroscience · 2023Article
- Tract profiles of the cerebellar peduncles in children who stutter.Brain structure & function · 2022Article
- Spatiotemporal changes in along-tract profilometry of cerebellar peduncles in cerebellar mutism syndrome.NeuroImage. Clinical · 2022Article
- The impact of cerebellar transcranial direct current stimulation (tDCS) on sensorimotor and inter-sensory temporal recalibration.Frontiers in human neuroscience · 2022Article
- Contributions of Cerebellar White Matter Microstructure to Social Difficulty in Nonverbal Learning Disability.Cerebellum (London, England) · 2021Article
- Resection of cerebellar tumours causes widespread and functionally relevant white matter impairments.Human brain mapping · 2021Article
- Speech rate association with cerebellar white-matter diffusivity in adults with persistent developmental stuttering.Brain structure & function · 2021Article
- Cerebellar White Matter Structural Correlates of Locomotor Adaptation. Do They Reflect Neural Adaptation?Cerebellum (London, England) · 2020Article
- White matter correlates of sensorimotor synchronization in persistent developmental stuttering.Journal of communication disordersArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
In sensorimotor adaptation paradigms, participants learn to adjust their behavior in response to an external perturbation. Locomotor adaptation and reaching adaptation depend on the cerebellum and are accompanied by changes in functional connectivity in cortico-cerebellar circuits. In order to gain a better understanding of the particular cerebellar projections involved in locomotor adaptation, we assessed the contribution of specific white matter pathways to the magnitude of locomotor adaptation and to long-term motor adaptation effects (recall and relearning). Diffusion magnetic resonance imaging with deterministic tractography was used to delineate the inferior and superior cerebellar peduncles (ICP, SCP) and the corticospinal tract (CST). Correlations were calculated to assess the association between the diffusivity values along the tracts and behavioral measures of locomotor adaptation. The results point to a significant correlation between the magnitude of adaptation and diffusivity values in the left ICP. Specifically, a higher magnitude of adaptation was associated with higher mean diffusivity and with lower anisotropy values in the left ICP, but not in other pathways. Post hoc analysis revealed that the effect stems from radial, not axial, diffusivity. The magnitude of adaptation was further associated with the degree of ICP lateralization, such that greater adaptation magnitude was correlated with increased rightward asymmetry of the ICP. Our findings suggest that the magnitude of locomotor adaptation depends on afferent signals to the cerebellum, transmitted via the ICP, and point to the contribution of error detection to locomotor adaptation rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.