Evidence map›Paper›PMID 32034650›Full record

ArticleJournal of autism and developmental disorders2020

Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder.

Paul A Constable, Edward R Ritvo, Ariella R Ritvo, Irene O Lee, Morgan L McNair, Dylan Stahl, Jane Sowden, Stephen Quinn, David H Skuse, Dorothy A Thompson and 1 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Retinal GABAergic Alterations in Adults with Autism Spectrum Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Atypical Retinal Ganglion Cell Function in a Mouse Model of Fragile X Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  12. Review
  13. Ocular manifestations in autism spectrum disorder.International journal of ophthalmology · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Paul A ConstableCaring Futures Institute, College of Nursing and Health Sciences, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia. Paul.Constable@flinders.edu.au.ORCID http://orcid.org/0000-0002-3994-1700
Edward R RitvoProfessor Emeritus, UCLA, Los Angeles, CA, USA.
Ariella R RitvoChild Study Center, Yale University School of Medicine, New Haven, CT, USA.
Irene O LeeBehavioural and Brain Sciences Unit, Population Policy and Practice Programme, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Morgan L McNairDepartment of Psychology, Stony Brook University, New York, NY, USA.
Dylan StahlSchool of Medicine, Washington University, St Louis, MO, USA.
Jane SowdenNIHR Great Ormond Street Hospital Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Stephen QuinnDepartment of Statistics, Data Science and Epidemiology, Swinburne University of Technology, Melbourne, Australia.
David H SkuseBehavioural and Brain Sciences Unit, Population Policy and Practice Programme, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Dorothy A ThompsonThe Tony Kriss Visual Electrophysiology Unit, Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children NHS Trust, London, UK.
James C McPartlandChild Study Center, Yale University School of Medicine, New Haven, CT, USA.

Funding

The Autism Biomarkers Consortium for Clinical TrialsU19MH108206 · NIMH · YALE UNIVERSITY · PI DZIURA, JAMES DAVID · 2015 to 2024
$68.8M
National Institute of Health Research (US) R01 MH100173.NIH HHS U19 MH108206
6 · The paper itself

Abstract

Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m

Indexed as

AdolescentAutism Spectrum DisorderCase-Control StudiesElectroretinographyFemaleHumansModels, BiologicalPhotic StimulationRetinaAutism spectrum disorderb-waveElectroretinogram

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.