Evidence map›Paper›PMID 32034643›Full record

ArticleCardiovascular drugs and therapy2020

MicroRNA-205-5p Promotes Unstable Atherosclerotic Plaque Formation In Vivo.

Xiandong Meng, Jianjiao Yin, Xinli Yu, Yonggang Guo

Abstract read
PubMed Publisher
In one paragraph

Article in Cardiovascular drugs and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xiandong MengDepartment of Cardiology, The First People's Hospital of Keerqin District, No. 328, Keerqin Street, Keerqin District, Tongliao City, Inner Mongolia, China. 308740952@qq.com.
Jianjiao YinDepartment of Ophthalmology, The First People's Hospital of Keerqin District, Tongliao City, Inner Mongolia, China.
Xinli YuDepartment of Cardiology, The First People's Hospital of Keerqin District, No. 328, Keerqin Street, Keerqin District, Tongliao City, Inner Mongolia, China.
Yonggang GuoDepartment of Medical Service, The First People's Hospital of Keerqin District, Tongliao City, Inner Mongolia, China.
Keihin (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAtherosclerosis is a narrowing of the arteries caused by plaque buildup. MicroRNAs (miRNAs) have been proposed to participate in the pathogenesis of atherosclerosis. Here, we aimed to investigate miR-205-5p's role in promoting atherosclerotic progression.

methodsKnock-in (KI) mice with human/murine miR-205-5p within the murine host gene for miR-205 (MIR205HG) were crossed with apolipoprotein E knockout (Apoe

resultsmiR-205KI Apoe

conclusionsmiR-205-5p encourages unstable atherogenesis in vivo. miR-205-5p also adversely influences lipid metabolism and promotes a pro-inflammatory macrophage phenotype. Our findings advocate miR-205-5p as a potential therapeutic target for combating unstable atherogenesis.

Indexed as

Plaque, AtheroscleroticAnimalsAortaAortic DiseasesApoptosisAtherosclerosisBone Marrow TransplantationCase-Control StudiesCholesterol, HDLDisease Models, AnimalDisease ProgressionHumansMacrophagesMembrane MicrodomainsMice, Inbred C57BLMice, Knockout, ApoECholesterol, HDLMicroRNAsMIR205, humanMIRN205 microRNA, mouseTriglyceridesAtherosclerosisCholesterolLipidmiR-205Unstable plaque

Identifiers

PMID32034643
OpenAlexW3004850815

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.