ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2021
Medium-term results of cardioneuroablation for clinical bradyarrhythmias and vasovagal syncope: effects on QT interval and heart rate.
Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Durable Physiological Changes and Decreased Syncope Burden 12 Months After Unifocal Right-Sided Ablation Under Computed Tomographic Guidance in Patients With Neurally Mediated Syncope or Functional Sinus Node Dysfunction.Circulation. Arrhythmia and electrophysiology · 2021Trial
- Cardioneuroablation for Reflex Syncope and Functional Bradyarrhythmias: A State-of-the-Art Review.Journal of clinical medicine · 2026Review
- Cardioneuroablation versus cardiac pacemaker in the management of dominant cardioinhibitory vasovagal syncope: a retrospective cohort study.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Enhanced mapping and targeting of ganglionated plexi using peak frequency analysis in cardioneuroablation: a study in autonomic cardiac disorders.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Efficacy and safety of cardioneuroablation as a treatment for patients with functional bradyarrhythmia: a systematic review and meta-analysis.International journal of cardiology. Heart & vasculature · 2026Review
- Cardioneuroablation for Vasovagal Syncope: An Updated Systematic Review and Single-Arm Meta-Analysis.Biomedicines · 2025Review
- Improved health-related quality of life after cardioneuroablation in patients with vasovagal syncope.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Quality of life improvement following cardioneuroablation for vasovagal syncope: expected or too early to say?Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Permanent pacing versus cardioneuroablation for cardioinhibitory vasovagal syncope.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Cardiac parasympathetic denervation reduces hypoxic tachycardia, baroreflex sensitivity and heart rate variability in humans.Scientific reports · 2025Article
- Catheter Ablation for Vasovagal Syncope: The Therapeutic Potential of Gateway Plexi.Arrhythmia & electrophysiology review · 2025Review
- Cardioneuroablation can be an effective strategy to treat glossopharyngeal neuralgia-related sinus bradycardia and pauses.Journal of cardiovascular electrophysiology · 2024Article
- Effectiveness of cardioneuroablation in different subtypes of vasovagal syncope.Journal of geriatric cardiology : JGC · 2024Article
- Cardioneuroablation as a strategy to prevent pacemaker implantation in young patients with vasovagal syncope.International journal of cardiology. Heart & vasculature · 2024Article
- Selection of patients with symptomatic vagal-induced sinus node dysfunction: Who will be the best candidate for cardioneuroablation?Frontiers in physiology · 2023Review
- Cardioneuroablation for successful treatment of symptomatic bradycardia in a 12-year-old child after a 6-month follow-up.Frontiers in cardiovascular medicine · 2023Article
- Cardioneuroablation for Treating Vasovagal Syncope: Current Status and Future Directions.Arrhythmia & electrophysiology review · 2023Review
- Long-term Success of Partial Ganglionated Plexus Ablation in a Patient with Tachycardia-bradycardia Syndrome and Syncope: Whom and How?The Journal of innovations in cardiac rhythm management · 2021Article
- Potential therapeutic effects of electrogram-guided cardioneuroablation in long QT syndrome: case series.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021Article
- Evaluation of acute alterations in electrocardiographic parameters after cryoballoon ablation of atrial fibrillation and possible association with recurrence.Anatolian journal of cardiology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough parasympathetic effects of cardioneuroablation (CNA) in vagally mediated bradyarrhythmias (VMB) were studied, sympathetic effects have not been elucidated, yet. We aimed to investigate the acute and medium-term outcomes of CNA as well as the impact of CNA on ventricular repolarization by using corrected QT interval (QTc) measurements.
methodsSixty-five patients (58.5% men; age 39.4 ± 14 years) undergoing CNA were included in the study. Patients who underwent CNA due to VMB were divided into two groups: (1) bi-atrial CNA and (2) right-sided CNA. QTc was calculated at 3 time points: before the procedure (time point 1); 24 h post-ablation (time point 2); and at the last follow-up visit (time point 3).
resultsThe mean follow-up time was 20.0 ± 20 months. Acute success was achieved in 64 (98.4%) of cases. In the whole cohort, from time point 1 to 2, a significant shortening in QTcFredericia, QTcFramingham, and QTcHodges was observed which remained lower than baseline in time point 3. Although the difference between measurements in time point 1 and 2 was not statistically significant for QTcBazett, a significant shortening was detected between time point 1 and 3. There was significant difference between groups for shortening in QTcFredericia and QTcFramingham (p = 0.01). Event-free survival was detected in 90.7% (59/65) of cases.
conclusionsOur results demonstrate a significant shortening of QTc in addition to high acute and medium-term success rates after CNA. The most likely mechanism is the effect of CNA on the sympathetic system as well as on the parasympathetic system. Bi-atrial ablation was found related to higher QTc shortening effect.
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