ArticleAnnals of biomedical engineering2020
Fluid-Structure Interaction Models of Bioprosthetic Heart Valve Dynamics in an Experimental Pulse Duplicator.
Article in Annals of biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 96 citations in OpenAlex.
- Patient-Specific Analysis of Ventricular Vortex Formation and Flow Energetics in Rheumatic and Calcific Mitral Stenosis.Annals of biomedical engineering · 2026Article
- Simulations predict improved valve performance without direct leaflet intervention after neonatal truncus arteriosus repair.The Journal of thoracic and cardiovascular surgery · 2026Article
- Mechanical-medical convergence in heart failure: Artificial intelligence, finite-element modeling, and 3D printing for diagnosis and prognosis.Bioengineering & translational medicine · 2026Review
- Article
- An open-source computational framework for immersed fluid-structure interaction modeling using FEBio and MFEM.Engineering with computers · 2026Article
- Fluid-structure interaction analysis of aortic valve dynamics: effects of aspect ratio.Regenerative biomaterials · 2026Article
- A numerical framework for preprocedural prosthetic valve positioning and hemodynamic evaluation.Biomechanics and modeling in mechanobiology · 2025Article
- In Silico and In Vitro Comparison of Seven Closed and Semi-Closed Leaflet Designs for Transcatheter Heart Valve Replacements.Bioengineering (Basel, Switzerland) · 2025Article
- A fluid-structure interaction model of the zebrafish aortic valve.Journal of biomechanics · 2025Article
- LOCAL DIVERGENCE-FREE IMMERSED FINITE ELEMENT-DIFFERENCE METHOD USING COMPOSITE B-SPLINES.Advances in computational science and engineering · 2025Article
- Computational construction and design optimization of a novel tri-tube heart valve.Biomechanics and modeling in mechanobiology · 2025Article
- Article
- Multiscale structure and function of the aortic valve apparatus.Physiological reviews · 2024Review
- Simulating cardiac fluid dynamics in the human heart.PNAS nexus · 2024Article
- Credibility assessment of in silico clinical trials for medical devices.PLoS computational biology · 2024Review
- Computational Fluid-Structure Interaction in Microfluidics.Micromachines · 2024Review
- Influence of Polymer Stiffness and Geometric Design on Fluid Mechanics in Tissue-Engineered Pulmonary Valve Scaffolds.Annals of biomedical engineering · 2024Article
- Regulatory science promotes the translation of transcatheter tricuspid valve repair/replacement devices.Regenerative biomaterials · 2024Article
- Altered blood flow due to larger aortic diameters in patients with transcatheter heart valve thrombosis.APL bioengineering · 2023Article
- An immersed peridynamics model of fluid-structure interaction accounting for material damage and failure.Journal of computational physics · 2023Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Computer modeling and simulation is a powerful tool for assessing the performance of medical devices such as bioprosthetic heart valves (BHVs) that promises to accelerate device design and regulation. This study describes work to develop dynamic computer models of BHVs in the aortic test section of an experimental pulse-duplicator platform that is used in academia, industry, and regulatory agencies to assess BHV performance. These computational models are based on a hyperelastic finite element extension of the immersed boundary method for fluid-structure interaction (FSI). We focus on porcine tissue and bovine pericardial BHVs, which are commonly used in surgical valve replacement. We compare our numerical simulations to experimental data from two similar pulse duplicators, including a commercial ViVitro system and a custom platform related to the ViVitro pulse duplicator. Excellent agreement is demonstrated between the computational and experimental results for bulk flow rates, pressures, valve open areas, and the timing of valve opening and closure in conditions commonly used to assess BHV performance. In addition, reasonable agreement is demonstrated for quantitative measures of leaflet kinematics under these same conditions. This work represents a step towards the experimental validation of this FSI modeling platform for evaluating BHVs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.