Evidence map›Paper›PMID 32034564›Full record

ReviewNeurosurgical review2021

Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms.

Joona Hallikainen, Sara Keränen, Jarno Savolainen, Matti Närhi, Anna Liisa Suominen, Pekka Ylöstalo, Jari Kellokoski, Mikko Pyysalo, Pirkko Pussinen, Tuomas Rauramaa and 1 more

Open access · hybridAbstract readReview
In one paragraph

Review in Neurosurgical review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Microorganisms · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Joona HallikainenInstitute of Dentistry, University of Eastern Finland, Kuopio, Finland. joona.hallikainen@kuh.fi.ORCID http://orcid.org/0000-0002-2875-3659
Sara KeränenHemorrhagic Brain Pathology Research Group, Kuopio University Hospital, Kuopio, Finland.
Jarno SavolainenInstitute of Dentistry, University of Eastern Finland, Kuopio, Finland.
Matti NärhiInstitute of Dentistry, University of Eastern Finland, Kuopio, Finland.
Anna Liisa SuominenInstitute of Dentistry, University of Eastern Finland, Kuopio, Finland.
Pekka YlöstaloMedical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.
Jari KellokoskiInstitute of Dentistry, University of Eastern Finland, Kuopio, Finland.
Mikko PyysaloHemorrhagic Brain Pathology Research Group, Tampere University Hospital and University of Tampere, Tampere, Finland.
Pirkko PussinenOral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Tuomas RauramaaDepartment of Pathology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.
Juhana FrösenHemorrhagic Brain Pathology Research Group, Kuopio University Hospital, Kuopio, Finland.
University of Eastern Finland · FIKuopio University Hospital · FIOulu University Hospital · FITampere University Hospital · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Degeneration of intracranial aneurysm wall is under active research and recent studies indicate an increased risk of rupture of intracranial aneurysm among patients with periodontal diseases. In addition, oral bacterial DNA has been identified from wall samples of ruptured and unruptured aneurysms. These novel findings led us to evaluate if oral diseases could predispose to pathological changes seen on intracranial aneurysm walls eventually leading to subarachnoid hemorrhage. The aim of this review is to consider mechanisms on the relationship between periodontitis and aneurysm rupture, focusing on recent evidence.

Indexed as

Aneurysm, RupturedHumansIntracranial AneurysmMouthPeriodontal DiseasesSubarachnoid HemorrhageIntracranial aneurysmOral diseasesPathogensPeriodontitisSubarachnoidal hemorrhage

Identifiers

PMID32034564
PMCPMC7850994
OpenAlexW3005018838

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.