ReviewCurrent atherosclerosis reports2020
Mitral Annular Calcification: Association with Atherosclerosis and Clinical Implications.
Review in Current atherosclerosis reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Relationship Between Mitral Annular Calcification and Inflammatory Indices in Patients with Cardiometabolic Risk Factors.Biomedicines · 2026Article
- Mitral annular calcification: implications on clinical outcomes and interventions.Annals of cardiothoracic surgery · 2025Review
- Risk Factor Analysis and Predictive Nomogram for Heart Valve Calcification in Rheumatoid Arthritis.Reviews in cardiovascular medicine · 2025Article
- Mitral annular calcification in interventional cardiology: address all fears.AsiaIntervention · 2025Review
- Rethinking Mitral Annular Calcification and Its Clinical Significance: From Passive Process to Active Pathology.Journal of personalized medicine · 2024Review
- Noncontrast cardiac computed tomography-derived mitral annular calcification scores in mitral valve disease.Clinical cardiology · 2023Article
- The Role of Advanced Glycation End-Product Levels Measured by Skin Autofluorescence in the Development of Mitral Annular Calcification.Journal of cardiovascular development and disease · 2023Article
- Opportunistic screening at chest computed tomography: literature review of cardiovascular significance of incidental findings.Cardiovascular diagnosis and therapy · 2023Review
- Mitral Annular Calcification and Thromboembolic Risk.Life (Basel, Switzerland) · 2023Article
- Benign incidental cardiac findings in chest and cardiac CT imaging.The British journal of radiology · 2023Review
- Transcatheter edge-to-edge mitral valve repair in patients with mitral annulus calcification.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2022Article
- Extensive calcification of the mitral valve annulus in transcatheter aortic valve implants.Interactive cardiovascular and thoracic surgery · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThis review summarizes the pathophysiology of mitral annular calcification (MAC) with recent findings and current strategies for diagnosis and treatment. RECENT
findingsMajor factors in MAC development seem to be shear stress of the flow past the mitral valve, local inflammation, and dysregulation in regulators of mineral metabolism. MAC itself poses daunting technical challenges. Implanting a valve on top of the calcium bar might lead to paravalvular leak (PVL) that is less likely to heal. Annular decalcification allows for better valve seating and potentially better healing and less PVL. This, however, comes with the risk for catastrophic atrioventricular groove disruption. MAC can be sharply dissected with the scalpel; the annulus can be reconstructed with the autologous pericardium. Transcatheter mitral valve replacement is a promising approach in the treatment of patients who are deemed high-risk surgical candidates with severe MAC. MAC is a multifactorial disease that has some commonalities with atherosclerosis, mainly regarding lipid accumulation and calcium deposition. It is of great clinical importance, being a risk marker of cardiovascular events (including sudden death) and, with its progression, can have a negative impact on patients' lives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.