Evidence map›Paper›PMID 32034452›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2020

Testing a theoretical model of imminent fracture risk in elderly women: an observational cohort analysis of the Canadian Multicentre Osteoporosis Study.

A Papaioannou, J D Adachi, C Berger, Y Jiang, R Barron, J S McGinley, R J Wirth, T P Anastassiades, K S Davison, D A Hanley and 8 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 12 institutions in 2 countries.

A PapaioannouMcMaster University, Hamilton, ON, Canada.
J D AdachiMcMaster University, Hamilton, ON, Canada.
C BergerResearch Institute of the McGill University Health Centre, Montreal, QC, Canada.
Y JiangAmgen Inc., One Amgen Center Drive, Thousand Oaks, CA, 91320, USA. jiangyw26@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-0498-0662
R BarronAmgen Inc., One Amgen Center Drive, Thousand Oaks, CA, 91320, USA.
J S McGinleyVector Psychometric Group, LLC, Chapel Hill, NC, USA.
R J WirthVector Psychometric Group, LLC, Chapel Hill, NC, USA.
T P AnastassiadesQueen's University, Kingston, ON, Canada.
K S DavisonUniversity of Victoria, Victoria, BC, Canada.
D A HanleyCumming School of Medicine, University of Calgary, Calgary, AL, Canada.
G IoannidisMcMaster University, Hamilton, ON, Canada.
S M KaiserDalhousie University, Halifax, NS, Canada.
C S KovacsMemorial University of Newfoundland, St. John's, NL, Canada.
W D LeslieUniversity of Manitoba, Winnipeg, MB, Canada.
S N MorinMcGill University, Montreal, QC, Canada.
J C PriorUniversity of British Columbia, Vancouver, BC, Canada.
T TowheedQueen's University, Kingston, ON, Canada.
D GoltzmanMcGill University, Montreal, QC, Canada.
McMaster University · CAAmgen (United States) · USMcGill University · CAQueen's University · CAVector (United States) · USDalhousie University · CAMcGill University Health Centre · CAMemorial University of Newfoundland · CAUniversity of British Columbia · CAUniversity of Calgary · CAUniversity of Manitoba · CAUniversity of Victoria · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We examined the underlying relationship between fracture risk factors and their imminent risk. Results suggested that having past year fracture, worse past year general health, worse past year physical functioning, and lower past year BMD T-score directly predicted higher imminent fracture risk. Past year falls indirectly predicted imminent risk through physical functioning and general health.

introductionThis study aimed to examine direct and indirect effects of several factors on imminent (1 year) fracture risk.

methodsData from women age 65 and older from population-based Canadian Multicentre Osteoporosis Study were used. Predictors were identified from study years 5 and 10, and imminent fracture data (1-year fracture) came from years 6 and 11 (year 5 predicts year 6, year 10 predicts year 11). A structural equation model (SEM) was used to test the theoretical construct. General health and physical functioning were measured as latent variables using items from the 36-Item Short Form Health Survey (SF-36) and bone mineral density (BMD) T-score was a latent variable based on observed site-specific BMD data (spine L1-L4, femoral neck, total hip). Observed variables were fractures and falls. Model fit was evaluated using root mean square error of approximation (RMSEA), Tucker Lewis index (TLI), and comparative fit index (CFI).

resultsThe analysis included 3298 women. Model fit tests showed that the SEM fit the data well; χ

conclusionsWe found several direct and indirect pathways that predicted imminent fracture risk in elderly women. Future studies should extend this work by developing risk scoring methods and defining imminent risk thresholds.

Indexed as

Bone DensityAgedCanadaCohort StudiesFemaleFractures, BoneHumansModels, TheoreticalOsteoporosisRisk FactorsCaMosepidemiologyfracture riskimminentolder womenosteoporosis

Identifiers

PMID32034452
OpenAlexW3004759945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.