ArticleCell death and differentiation2020
Mutant GTF2I induces cell transformation and metabolic alterations in thymic epithelial cells.
Article in Cell death and differentiation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Distinct Associations ofGenes · 2026Article
- RNA biomarker signatures for prediction of acute kidney injury in acute coronary syndrome patients undergoing PCI.BMC nephrology · 2026Observational
- Low GBX2 expression is associated with histological type B thymoma: a multi-omics analysis.Discover oncology · 2026Article
- Current Clinical Paradigm and Therapeutic Advancements in Thymic Malignancies: A Narrative Review.Cancers · 2025Review
- Effects of the Different Dietary Fish Oil Calcium Salt on Production Performance, Blood Biochemical Parameters, Egg Quality Traits and Yolk Fatty Acid Profile in Laying Hens at Peak Production Period.Veterinary medicine and science · 2025Article
- Gtf2i-encoded transcription factor Tfii-i regulates myelination via Sox10 and Mbp regulatory elements.Nature communications · 2025Article
- Factors distinguishing thymomas from thymic squamous cell carcinoma: a proposal for diagnosis emphasizing the immunophenotype.Mediastinum (Hong Kong, China) · 2025Review
- Dietary bile acids supplementation decreases hepatic fat deposition with the involvement of altered gut microbiota and liver bile acids profile in broiler chickens.Journal of animal science and biotechnology · 2024Article
- Non-Mutational Key Features in the Biology of Thymomas.Cancers · 2024Review
- Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive FAT1 and inhibits stemness maintenance in thyroid carcinoma.Frontiers of medicine · 2023Article
- Genetic profile of thymic epithelial tumors in the Japanese population: an exploratory study examining potential therapeutic targets.Translational lung cancer research · 2023Article
- Somatic mutations of thymic epithelial tumors with myasthenia gravis.Frontiers in oncology · 2023Article
- Pathological snapshots of thymic epithelial tumors with invasion into neighboring structures: preparing for the forthcoming revision of the TNM classification.Mediastinum (Hong Kong, China) · 2023Review
- Transcription factor TFII-I fine tunes innate properties of B lymphocytes.Frontiers in immunology · 2023Article
- A Knock-In Mouse Model of Thymoma With the GTF2I L424H Mutation.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2022Article
- Human thymoma-associated mutation of the GTF2I transcription factor impairs thymic epithelial progenitor differentiation in mice.Communications biology · 2022Article
- The immune landscape of human thymic epithelial tumors.Nature communications · 2022Article
- Pan-cancer analysis of necroptosis-related gene signature for the identification of prognosis and immune significance.Discover oncology · 2022Article
- Novel Driver Strength Index highlights important cancer genes in TCGA PanCanAtlas patients.PeerJ · 2022Article
- A novel metabolic gene signature-based nomogram to predict overall survival in breast cancer.Annals of translational medicine · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
The pathogenesis of thymic epithelial tumors (TETs) is poorly understood. Recently we reported the frequent occurrence of a missense mutation in the GTF2I gene in TETs and hypothesized that GTF2I mutation might contribute to thymic tumorigenesis. Expression of mutant TFII-I altered the transcriptome of normal thymic epithelial cells and upregulated several oncogenic genes. Gtf2i L424H knockin cells exhibited cell transformation, aneuploidy, and increase tumor growth and survival under glucose deprivation or DNA damage. Gtf2i mutation also increased the expression of several glycolytic enzymes, cyclooxygenase-2, and caused modifications of lipid metabolism. Elevated cyclooxygenase-2 expression by Gtf2i mutation was required for survival under metabolic stress and cellular transformation of thymic epithelial cells. Our findings identify GTF2I mutation as a new oncogenic driver that is responsible for transformation of thymic epithelial cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.