Evidence map›Paper›PMID 32034255›Full record

Trial reportScientific reports2020

Plasma lipid profile associates with the improvement of psychological well-being in individuals with perceived stress symptoms.

Stefania Noerman, Anton Klåvus, Elina Järvelä-Reijonen, Leila Karhunen, Seppo Auriola, Riitta Korpela, Raimo Lappalainen, Urho M Kujala, Sampsa Puttonen, Marjukka Kolehmainen and 1 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Stefania NoermanInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.ORCID http://orcid.org/0000-0003-4615-7268
Anton KlåvusInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.
Elina Järvelä-ReijonenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.
Leila KarhunenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.
Seppo AuriolaSchool of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Riitta KorpelaMedical Faculty, Pharmacology and Human Microbe Research program, University of Helsinki, P.O. Box 63, FI-00014, Helsinki, Finland.
Raimo LappalainenDepartment of Psychology, Faculty of Education and Psychology, University of Jyväskylä, PO Box 35, FI-40014, Jyväskylä, Finland.
Urho M KujalaFaculty of Sport and Health Sciences, University of Jyväskylä, P.O. Box 35, FI-40014, Jyväskylä, Finland.ORCID http://orcid.org/0000-0002-9262-1992
Sampsa PuttonenFinnish Institute of Occupational Health, P.O. Box 40, FI-00251, Helsinki, Finland.ORCID http://orcid.org/0000-0002-7796-6941
Marjukka KolehmainenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland. marjukka.kolehmainen@uef.fi.ORCID http://orcid.org/0000-0002-3770-2538
Kati HanhinevaInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.
University of Eastern Finland · FIUniversity of Jyväskylä · FIFinnish Institute of Occupational Health · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psychological stress is a suggested risk factor of metabolic disorders, but molecular mediators are not well understood. We investigated the association between the metabolic profiles of fasting plasma and the improvement of psychological well-being using non-targeted liquid chromatography-mass spectrometry (LC-MS) platform. The metabolic profiles of volunteers participating in the face-to-face intervention group (n = 60) in a randomised lifestyle intervention were compared to ones of controls (n = 64) between baseline and 36-week follow-up. Despite modest differences in metabolic profile between groups, we found associations between phosphatidylcholines (PCs) and several parameters indicating stress, adiposity, relaxation, and recovery. The relief of heart-rate-variability-based stress had positive, while improved indices of recovery and relaxation in the intervention group had an inverse association with the reduction of e.g. lysophosphatidylcholines (LPC). Interleukin-1 receptor antagonist and adiposity correlated positively with the suppressed PCs and negatively with the elevated plasmalogens PC(P-18:0/22:6) and PC(P-18:0/20:4). Also, we found changes in an unknown class of lipids over time regardless of the intervention groups, which also correlated with physiological and psychological markers of stress. The associations between lipid changes with some markers of psychological wellbeing and body composition may suggest the involvement of these lipids in the shared mechanisms between psychological and metabolic health.

Indexed as

Healthy LifestyleAdiposityAdultBiomarkersDiagnostic Self EvaluationFemaleHumansMaleMetabolomeMiddle AgedPhosphatidylcholinesPlasmalogensStress, PsychologicalBiomarkersPhosphatidylcholinesPlasmalogens

Identifiers

PMID32034255
PMCPMC7005736
OpenAlexW3005218316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.