ArticleScientific reports2020
Context-Dependent Role of Vinculin in Neutrophil Adhesion, Motility and Trafficking.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
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- Comparative Transcriptomics Analysis Reveals Unique Immune Response to Grass Carp Reovirus Infection in Barbel Chub (Biology · 2024Article
- Exploring the dynamic behavior of leukocytes with zebrafish.Current opinion in cell biology · 2023Review
- Stages of NETosis Development upon Stimulation of Neutrophils with Activators of Different Types.International journal of molecular sciences · 2023Article
- Targeting Neutrophil βBiomolecules · 2023Review
- Scleral Proteome in Noninfectious Scleritis Unravels Upregulation of Filaggrin-2 and Signs of Neovascularization.Investigative ophthalmology & visual science · 2023Article
- The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses.Frontiers in immunology · 2023Article
- Endogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension.American journal of respiratory and critical care medicine · 2022Article
- HS1 deficiency protects against sepsis by attenuating neutrophil-inflicted lung damage.European journal of cell biology · 2022Article
- A core of differentially methylated CpG loci in gMDSCs isolated from neonatal and adult sources.Clinical epigenetics · 2022Article
- Expression of the phagocytic receptors αFrontiers in immunology · 2022Article
- Control of innate immune response by biomaterial surface topography, energy, and stiffness.Acta biomaterialia · 2021Review
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Neutrophils are innate immune effector cells that traffic from the circulation to extravascular sites of inflammation. β2 integrins are important mediators of the processes involved in neutrophil recruitment. Although neutrophils express the cytoskeletal protein vinculin, they do not form mature focal adhesions. Here, we characterize the role of vinculin in β2 integrin-dependent neutrophil adhesion, migration, mechanosensing, and recruitment. We observe that knockout of vinculin attenuates, but does not completely abrogate, neutrophil adhesion, spreading, and crawling under static conditions. However, we also found that vinculin deficiency does not affect these behaviors in the presence of forces from fluid flow. In addition, we identify a role for vinculin in mechanosensing, as vinculin-deficient neutrophils exhibit attenuated spreading on stiff, but not soft, substrates. Consistent with these findings, we observe that in vivo neutrophil recruitment into the inflamed peritoneum of mice remains intact in the absence of vinculin. Together, these data suggest that while vinculin regulates some aspects of neutrophil adhesion and spreading, it may be dispensable for β2 integrin-dependent neutrophil recruitment in vivo.
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Registered trials
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