Evidence map›Paper›PMID 32034152›Full record

ArticleNature communications2020

De novo strategy with engineering anti-Kasha/Kasha fluorophores enables reliable ratiometric quantification of biomolecules.

Limin Shi, Chenxu Yan, Zhiqian Guo, Weijie Chi, Jingle Wei, Weimin Liu, Xiaogang Liu, He Tian, Wei-Hong Zhu

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
6.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 107 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Limin Shi *Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China.ORCID http://orcid.org/0000-0002-0594-8904
Chenxu Yan *Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China.ORCID http://orcid.org/0000-0001-7130-769X
Zhiqian GuoKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China. guozq@ecust.edu.cn.ORCID http://orcid.org/0000-0002-2192-825X
Weijie ChiScience and Math Cluster, Singapore University of Technology and Design, 8 Somapah Road, Singapore, 487372, Singapore.ORCID http://orcid.org/0000-0003-1776-0025
Jingle WeiSchool of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, China.ORCID http://orcid.org/0000-0001-9915-3733
Weimin LiuSchool of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, China.ORCID http://orcid.org/0000-0002-9359-1465
Xiaogang LiuScience and Math Cluster, Singapore University of Technology and Design, 8 Somapah Road, Singapore, 487372, Singapore. xiaogang_liu@sutd.edu.sg.ORCID http://orcid.org/0000-0002-2553-2068
He TianKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China.ORCID http://orcid.org/0000-0003-3547-7485
Wei-Hong ZhuKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China. whzhu@ecust.edu.cn.ORCID http://orcid.org/0000-0001-9103-166X
East China University of Science and Technology · CNShanghaiTech University · CNSingapore University of Technology and Design · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluorescence-based technologies have revolutionized in vivo monitoring of biomolecules. However, significant technical hurdles in both probe chemistry and complex cellular environments have limited the accuracy of quantifying these biomolecules. Herein, we report a generalizable engineering strategy for dual-emission anti-Kasha-active fluorophores, which combine an integrated fluorescein with chromene (IFC) building block with donor-π-acceptor structural modification. These fluorophores exhibit an invariant near-infrared Kasha emission from the S

Indexed as

A549 CellsAnimalsBenzopyransBiochemistryCysteineFemaleFluoresceinFluorescent DyesGlutathioneHep G2 CellsHumansMice, Inbred BALB CMolecular ImagingMolecular StructureNeoplasms, ExperimentalPyransBenzopyransCysteinedicyanomethylene-4H-pyranFluoresceinFluorescent DyesGlutathionePyransSpironolactone

Identifiers

PMID32034152
PMCPMC7005775
OpenAlexW3004997081

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.