Evidence map›Paper›PMID 32034138›Full record

ArticleNature communications2020

TBC1D9 regulates TBK1 activation through Ca

Takashi Nozawa, Shunsuke Sano, Atsuko Minowa-Nozawa, Hirotaka Toh, Shintaro Nakajima, Kazunori Murase, Chihiro Aikawa, Ichiro Nakagawa

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Restricting intracellularAutophagy · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Interplay between group AMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Mitochondria inInternational journal of molecular sciences · 2022
    Review
  19. Review
  20. Antioxidants (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Takashi NozawaDepartment of Microbiology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.ORCID http://orcid.org/0000-0002-1822-5553
Shunsuke SanoDepartment of Microbiology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Atsuko Minowa-NozawaDepartment of Microbiology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Hirotaka TohDepartment of Microbiology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Shintaro NakajimaDepartment of Life Science Dentistry, The Nippon Dental University, Tokyo, 102-8159, Japan.ORCID http://orcid.org/0000-0003-4858-3391
Kazunori MuraseDepartment of Microbiology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Chihiro AikawaDepartment of Microbiology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Ichiro NakagawaDepartment of Microbiology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan. nakagawa.ichiro.7w@kyoto-u.ac.jp.ORCID http://orcid.org/0000-0001-6552-1702
Kyoto University · JPNippon Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Invading microbial pathogens can be eliminated selectively by xenophagy. Ubiquitin-mediated autophagy receptors are phosphorylated by TANK-binding kinase 1 (TBK1) and recruited to ubiquitinated bacteria to facilitate autophagosome formation during xenophagy, but the molecular mechanism underlying TBK1 activation in response to microbial infection is not clear. Here, we show that bacterial infection increases Ca

Indexed as

AutophagyBinding SitesCalcium-Binding ProteinsCalcium SignalingCytosolGene Knockout TechniquesHeLa CellsHost-Pathogen InteractionsHumansMacroautophagyMembrane ProteinsMitochondriaPhosphorylationProtein Serine-Threonine KinasesStreptococcal InfectionsStreptococcus pyogenesCalcium-Binding ProteinsMembrane ProteinsProtein Serine-Threonine KinasesTBC1D9 protein, humanTBK1 protein, humanUbiquitin

Identifiers

PMID32034138
PMCPMC7005872
OpenAlexW3004803684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.