ArticleNature communications2020
Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration.
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Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
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Who cites it
72 citing papers in PubMed, 103 citations in OpenAlex.
- Insights into the modulation of age-related macular degeneration: Molecular and systems-level perspectives.Acta ophthalmologica · 2026Article
- Apolipoprotein E2/2 (APOE2/2) Genotype Is Associated With Reduced Choroidal Thickness.Investigative ophthalmology & visual science · 2026Article
- The Biochemical and Genetic Architecture of Geographic Atrophy: The Role of the FHL-1/CFH Axis and the Paradigm of RNA Interference Therapeutics.Biomedicines · 2026Review
- Decoding the Factor H-Related Proteins: Gatekeepers of Complement Dysregulation in AMD.European journal of immunology · 2026Review
- Identification of novel blood-borne soluble binding partners of factor H-related proteins.Scientific reports · 2026Article
- Choriocapillaris Flow Signal Deficits Are Associated With AMD Onset and Early Progression Over Three Years: ALSTAR2 Follow-Up.Investigative ophthalmology & visual science · 2026Article
- TheOphthalmology science · 2026Article
- CTx001 for Geographic Atrophy: A Gene Therapy Expressing Soluble, Truncated Complement Receptor 1 (Mini-CR1).Ophthalmology science · 2026Article
- Efficacy and Safety of Efdamrofusp Alfa with Personalized Dosing Intervals in Neovascular Age-Related Macular Degeneration: A Phase II Trial.Ophthalmology science · 2026Article
- A new perspective on AMD pathogenesis: a sequential Factor H-centered view of complement dysregulation.Frontiers in immunology · 2026Review
- Common and rare variants in complement genes as biomarkers of COVID-19 infection and severity. A lesson to learn for emerging pathogens.Frontiers in immunology · 2026Article
- Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration.Journal of neuroinflammation · 2025Article
- Genetic Associations of Rod- and Cone-Mediated Vision in Aging and Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2025Article
- Exploring Therapeutic Targets for Age-Related Macular Degeneration From Circulating Proteins to Plasma Metabolites in the European Population.Translational vision science & technology · 2025Article
- Hallmarks of aging in age-related macular degeneration and age-related neurological disorders: novel insights into common mechanisms and clinical relevance.Eye (London, England) · 2025Review
- Elevated Plasma Complement Factors in CRB1-Associated Inherited Retinal Dystrophies.Investigative ophthalmology & visual science · 2025Article
- Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries.Nature genetics · 2024Article
- Age-Related Macular Degeneration (AMD): Pathophysiology, Drug Targeting Approaches, and Recent Developments in Nanotherapeutics.Medicina (Kaunas, Lithuania) · 2024Review
- The Complement System as a Therapeutic Target in Retinal Disease.Medicina (Kaunas, Lithuania) · 2024Review
- Exploration of potential novel drug targets for diabetic retinopathy by plasma proteome screening.Scientific reports · 2024Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors at 8 institutions in 5 countries.
Valentina Cipriani *William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, EC1M 6BQ, UK. v.cipriani@qmul.ac.uk.ORCID http://orcid.org/0000-0002-0839-9955
Laura Lorés-Motta *Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, 6525 GA, The Netherlands.
Fan HeDivision of Evolution and Genomic Sciences, Faculty of Biology Medicine and Health, School of Biological Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.ORCID http://orcid.org/0000-0003-2651-6518
Dina FathallaSystems Immunity URI, Division of Infection and Immunity, and UK DRI Cardiff, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK.ORCID http://orcid.org/0000-0003-3845-529X
Viranga TilakaratnaDivision of Evolution and Genomic Sciences, Faculty of Biology Medicine and Health, School of Biological Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
Selina McHargDivision of Evolution and Genomic Sciences, Faculty of Biology Medicine and Health, School of Biological Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
Nadhim BayattiDivision of Evolution and Genomic Sciences, Faculty of Biology Medicine and Health, School of Biological Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
İlhan E AcarDepartment of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, 6525 GA, The Netherlands.ORCID http://orcid.org/0000-0002-2078-9905
Carel B HoyngDepartment of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, 6525 GA, The Netherlands.
Sascha FauserDepartment of Ophthalmology, University Hospital of Cologne, Cologne, 50924, Germany.
Anthony T MooreUCL Institute of Ophthalmology, University College London, London, EC1V 9EL, UK.
John R W YatesUCL Institute of Ophthalmology, University College London, London, EC1V 9EL, UK.
Eiko K de JongDepartment of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, 6525 GA, The Netherlands.ORCID http://orcid.org/0000-0001-6520-0407
B Paul MorganSystems Immunity URI, Division of Infection and Immunity, and UK DRI Cardiff, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK.
Anneke I den HollanderDepartment of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, 6525 GA, The Netherlands.ORCID http://orcid.org/0000-0003-0634-5408
Paul N BishopDivision of Evolution and Genomic Sciences, Faculty of Biology Medicine and Health, School of Biological Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
Simon J ClarkDivision of Evolution and Genomic Sciences, Faculty of Biology Medicine and Health, School of Biological Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK. simon.clark@uni-tuebingen.de.ORCID http://orcid.org/0000-0001-8394-8355
Radboud University Nijmegen · NLUniversity of Manchester · GBCardiff University · GBMoorfields Eye Hospital NHS Foundation Trust · GBManchester Academic Health Science Centre · GBManchester Royal Eye Hospital · GBRoche (Switzerland) · CHUniversity College Hospital · GB
Funding
International Advancing genomics through the AMD Genomics Consortium (IAMDGC)R01EY022310 · NEI · VANDERBILT UNIVERSITY · PI BLANTON, SUSAN HALLORAN, HAINES, JONATHAN L · 2012 to 2024
$4.9MMedical Research Council G0000067Medical Research Council MR/K024418/1Medical Research Council MR/P025838/1NEI NIH HHS R01 EY022310NHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008I
Abstract
Age-related macular degeneration (AMD) is a leading cause of blindness. Genetic variants at the chromosome 1q31.3 encompassing the complement factor H (CFH, FH) and CFH related genes (CFHR1-5) are major determinants of AMD susceptibility, but their molecular consequences remain unclear. Here we demonstrate that FHR-4 plays a prominent role in AMD pathogenesis. We show that systemic FHR-4 levels are elevated in AMD (P-value = 7.1 × 10
Indexed as
Polymorphism, Single NucleotideAgedApolipoproteinsCapillariesCase-Control StudiesComplement ActivationComplement Factor HGenetic Predisposition to DiseaseGenome-Wide Association StudyHaplotypesHumansIntracellular Signaling Peptides and ProteinsLIM Domain ProteinsLiverMacular DegenerationMuscle ProteinsApolipoproteinsCFH protein, humanCFHR4 protein, humanComplement Factor HFHL1 protein, humanIntracellular Signaling Peptides and ProteinsLIM Domain ProteinsMuscle Proteins
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.