ArticleProceedings of the National Academy of Sciences of the United States of America2020
High-resolution structural insights into the heliorhodopsin family.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Resurrecting Full-Length Ancestral Schizorhodopsins and Heliorhodopsins with Structure-Guided, Indel-Aware Sequence Reconstruction.ACS omega · 2026Article
- CryoRhodopsins: A comprehensive characterization of a group of microbial rhodopsins from cold environments.Science advances · 2025Article
- Retinal to Retinal Energy Transfer in a Bistable Microbial Rhodopsin Dimer.Journal of the American Chemical Society · 2025Article
- Proteorhodopsin insights into the molecular mechanism of vectorial proton transport.Science advances · 2025Article
- Molecular properties of a viral heliorhodopsin, V2HeR2.Biophysics and physicobiology · 2025Article
- Solid-state NMR of the retinal protonated Schiff base in microbial rhodopsins.Magnetic resonance letters · 2024Review
- Heliorhodopsin-mediated light-modulation of ABC transporter.Nature communications · 2024Article
- Ecological roles of nano-picoplankton in stratified waters of an embayment in the southern Benguela.FEMS microbiology letters · 2024Article
- pH-Dependent Binding and Releasing Mechanism of Acetate in the Inner Water Cavity of Heliorhodopsin.Biochemistry · 2023Article
- Effects of the Unique Chromophore-Protein Interactions on the Primary Photoreaction of Schizorhodopsin.The journal of physical chemistry letters · 2023Article
- Expression of Xanthorhodopsin in Escherichia coli.The protein journal · 2023Article
- Flotillin-associated rhodopsin (FArhodopsin), a widespread paralog of proteorhodopsin in aquatic bacteria with streamlined genomes.mSystems · 2023Article
- Mirror proteorhodopsins.Communications chemistry · 2023Article
- Heliorhodopsin Helps Photolyase to Enhance the DNA Repair Capacity.Microbiology spectrum · 2022Article
- Proton transfer and conformational changes along the hydrogen bond network in heliorhodopsin.Communications biology · 2022Article
- Heliorhodopsin binds and regulates glutamine synthetase activity.PLoS biology · 2022Article
- Article
- Low pH structure of heliorhodopsin reveals chloride binding site and intramolecular signaling pathway.Scientific reports · 2022Article
- Application of direct electrometry in studies of microbial rhodopsins reconstituted in proteoliposomes.Biophysical reviews · 2022Review
- Mechanisms of membrane protein crystallization in 'bicelles'.Scientific reports · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rhodopsins are the most abundant light-harvesting proteins. A new family of rhodopsins, heliorhodopsins (HeRs), has recently been discovered. Unlike in the known rhodopsins, in HeRs the N termini face the cytoplasm. The function of HeRs remains unknown. We present the structures of the bacterial HeR-48C12 in two states at the resolution of 1.5 Å, which highlight its remarkable difference from all known rhodopsins. The interior of HeR's extracellular part is completely hydrophobic, while the cytoplasmic part comprises a cavity (Schiff base cavity [SBC]) surrounded by charged amino acids and containing a cluster of water molecules, presumably being a primary proton acceptor from the Schiff base. At acidic pH, a planar triangular molecule (acetate) is present in the SBC. Structure-based bioinformatic analysis identified 10 subfamilies of HeRs, suggesting their diverse biological functions. The structures and available data suggest an enzymatic activity of HeR-48C12 subfamily and their possible involvement in fundamental redox biological processes.
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