ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2020
Polygenic Risk Score-Derived Subcortical Connectivity Mediates Attention-Deficit/Hyperactivity Disorder Diagnosis.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic Review: How the Attention-Deficit/Hyperactivity Disorder Polygenic Risk Score Adds to Our Understanding of ADHD and Associated Traits.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Pooled it
- Genetics of OCD and Related Disorders; Searching for Shared Factors.Current topics in behavioral neurosciences · 2021Pooled it
- Individual differences in effects of stressful life events on childhood ADHD: genetic, neural, and familial contributions.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Genetic Etiology Link to Brain Function Underlying ADHD Symptoms and its Interaction with Sleep Disturbance: An ABCD Study.Neuroscience bulletin · 2025Article
- Using polygenic scores in combination with symptom rating scales to identify attention-deficit/hyperactivity disorder.BMC psychiatry · 2024Article
- A precision functional atlas of personalized network topography and probabilities.Nature neuroscience · 2024Article
- Cumulative Effects of Resting-State Connectivity Across All Brain Networks Significantly Correlate with Attention-Deficit Hyperactivity Disorder Symptoms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Attention-deficit/hyperactivity disorder.Nature reviews. Disease primers · 2024Review
- Shared genetic etiology between ADHD, task-related behavioral measures and brain activation during response inhibition in a youth ADHD case-control study.European archives of psychiatry and clinical neuroscience · 2024Article
- Article
- The Oregon ADHD-1000: A new longitudinal data resource enriched for clinical cases and multiple levels of analysis.Developmental cognitive neuroscience · 2023Article
- Genetic influence on brain volume alterations related to self-reported childhood abuse.Frontiers in neuroscience · 2022Article
- Genetics in the ADHD Clinic: How Can Genetic Testing Support the Current Clinical Practice?Frontiers in psychology · 2022Review
- Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume.Translational psychiatry · 2021Article
- Neuroimaging in attention-deficit/hyperactivity disorder.Current opinion in psychiatry · 2021Review
- The stress-Wnt-signaling axis: a hypothesis for attention-deficit hyperactivity disorder and therapy approaches.Translational psychiatry · 2020Review
- Genetic and environmental contributions to individual differences in visual attention and oculomotor control in early infancy.Child developmentArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundAttention-deficit/hyperactivity disorder (ADHD) has substantial heritability, and a recent large-scale investigation has identified common genome-wide significant loci associated with increased risk for ADHD. Along the same lines, many studies using noninvasive neuroimaging have identified differences in brain functional connectivity in children with ADHD. We attempted to bridge these studies to identify differences in functional connectivity associated with common genetic risk for ADHD using polygenic risk score (PRS).
methodsWe computed ADHD PRSs for all participants in our sample (N = 315, children 7-13 years of age, 196 with ADHD and 119 unaffected comparison children) using ADHD data from the Psychiatric Genomics Consortium as a discovery set. Magnetic resonance imaging was used to evaluate resting-state functional connectivity of targeted subcortical structures.
resultsThe functional connectivity between 2 region pairs demonstrated a significant correlation to PRS: right caudate-parietal cortex and nucleus accumbens-occipital cortex. Connectivity between these areas, in addition to being correlated with PRS, was correlated with ADHD status. The connection between the caudate and the parietal region acted as a statistical suppressor, such that when it was included in a path model, the association between PRS and ADHD status was enhanced.
conclusionsOur results suggest that functional connectivity to certain subcortical brain regions is directly altered by genetic variants, and certain cortico-subcortical connections may modulate ADHD-related genetic effects.
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