Evidence map›Paper›PMID 32033845›Full record

ArticleClinical nutrition (Edinburgh, Scotland)2020

Dietary macronutrient intake and molecular-bacterial vaginosis: Role of fiber.

Rupak Shivakoti, Susan Tuddenham, Laura E Caulfield, Catherine Murphy, Courtney Robinson, Jacques Ravel, Khalil G Ghanem, Rebecca M Brotman

Open access · greenAbstract read
In one paragraph

Article in Clinical nutrition (Edinburgh, Scotland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Carbohydrate Intake and Bacterial Vaginosis: A Systematic Review.American journal of lifestyle medicine · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Dietary habits and vaginal environment: can a beneficial impact be expected?Frontiers in cellular and infection microbiology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Rupak ShivakotiDepartment of Epidemiology, Columbia University Mailman School of Public Health, New York, 10032, USA. Electronic address: rs3895@cumc.columbia.edu.
Susan TuddenhamDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, 21224, USA. Electronic address: studden1@jhmi.edu.
Laura E CaulfieldCenter for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA. Electronic address: lcaulfi1@jhu.edu.
Catherine MurphyDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, 21224, USA. Electronic address: catracmurphy@gmail.com.
Courtney RobinsonInstitute for Genome Science, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. Electronic address: courtneykrobinson@gmail.com.
Jacques RavelInstitute for Genome Science, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. Electronic address: jravel@som.umaryland.edu.
Khalil G GhanemDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, 21224, USA. Electronic address: kghanem@jhmi.edu.
Rebecca M BrotmanInstitute for Genome Science, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. Electronic address: rbrotman@som.umaryland.edu.
Johns Hopkins University · USUniversity of Maryland, Baltimore · USColumbia University Irving Medical Center · US

Funding

Duration of Hormonal Contraceptive Use: Immune Responses & Vaginal MicrobiotaR01AI089878 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GHANEM, KHALIL G · 2011 to 2015
$3.4M
Dysbiosis, Recurrent Bacterial Vaginosis and the Vaginal MicrobiomeK23AI125715 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TUDDENHAM, SUSAN ANNE · 2016 to 2020
$972k
MATERNAL INFLAMMATION, DIET AND GUT MICROBIOME IN HIV: IMPACT ON INFANT OUTCOMESR00HD089753 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHIVAKOTI, RUPAK · 2018 to 2020
$731k
NIAID NIH HHS K23 AI125715NIAID NIH HHS R01 AI089878NICHD NIH HHS R00 HD089753
6 · The paper itself

Abstract

BACKGROUND &

aimsWomen with bacterial vaginosis (BV) have increased risk of sexually transmitted infections and other adverse health outcomes. Based on the composition of their vaginal microbiota, women can broadly be classified into low-Lactobacillus (termed molecular-BV) and Lactobacillus-dominated profiles. Our objective was to determine the association between dietary macronutrient intake and molecular-BV.

methodsIn a cross-sectional study of 104 reproductive-age women, dietary intake data were obtained using the Block Brief 2000 food frequency questionnaire. Vaginal microbiota composition was characterized by sequencing amplicons of the 16S rRNA gene V3-V4 regions and clustering into community state types (CST). Logistic regression was used to determine the association of macronutrient intake with molecular-BV (low-Lactobacillus vs. Lactobacillus-dominated CSTs combined).

resultsParticipants had a median age of 25.9 (interquartile range: 21.9-29.6), 58% were white (30% black), 51% overweight/obese and 52% on hormonal contraception. In multivariable models, diets richer in fiber were inversely associated with molecular-BV (adjusted odds ratio: 0.49 per standard deviation increase in energy-adjusted fiber intake, 95% confidence interval: 0.24-0.99; p = 0.049).

conclusionsOur results indicate that diets richer in fiber were associated with lower odds of molecular-BV. Further studies are needed to confirm these findings and to test whether increasing fiber intake can modulate the microbiota towards a more optimal Lactobacillus-dominant profile.

Indexed as

AdultCross-Sectional StudiesDietary FiberFemaleHumansLactobacillusNutritional StatusNutritive ValueProtective FactorsRibotypingRisk AssessmentRisk FactorsVaginaVaginosis, BacterialYoung AdultDietary FiberDietFiberMicrobiomeNutritionVaginal microbiota

Identifiers

PMID32033845
PMCPMC7387193
OpenAlexW3003432690

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.