Trial reportThe Journal of pediatrics2020
Mortality and Neurodevelopmental Outcomes in the Heart Rate Characteristics Monitoring Randomized Controlled Trial.
Trial report in The Journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Heart Rate Characteristics Monitoring for Late-Onset Sepsis in Preterm Infants: A Systematic Review.Neonatology · 2023Pooled it
- Hypothermia association with all-cause mortality in critically ill patients with sepsis based on the MIMIC-IV database.Scientific reports · 2025Article
- Machine Learning Models as Early Warning Systems for Neonatal Infection.Clinics in perinatology · 2025Review
- The principles of whole-hospital predictive analytics monitoring for clinical medicine originated in the neonatal ICU.NPJ digital medicine · 2022Review
- Discovery of signatures of fatal neonatal illness in vital signs using highly comparative time-series analysis.NPJ digital medicine · 2022Article
- Cost-effectiveness analysis of heart rate characteristics monitoring to improve survival for very low birth weight infants.Frontiers in health services · 2022Article
- The Future of Outcome Prediction for Preterm Infants in the Neonatal ICU.American journal of respiratory and critical care medicine · 2022Article
- Ideal algorithms in healthcare: Explainable, dynamic, precise, autonomous, fair, and reproducible.PLOS digital health · 2022Article
- External validation of a novel signature of illness in continuous cardiorespiratory monitoring to detect early respiratory deterioration of ICU patients.Physiological measurement · 2021Article
- Principles for Real-World Implementation of Bedside Predictive Analytics Monitoring.Applied clinical informatics · 2021Article
- Coronavirus Disease 2019 Calls for Predictive Analytics Monitoring-A New Kind of Illness Scoring System.Critical care explorations · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
objectiveTo test whether the composite outcome of death or neurodevelopmental impairment (NDI) at 18-22 months corrected age for infants ≤1000 g at birth is decreased by continuous monitoring of heart rate characteristics during neonatal intensive care. STUDY
designWe studied a subset of participants enrolled in a multicenter randomized trial of heart rate characteristics monitoring. Survivors were evaluated at 18-22 months corrected age with a standardized neurologic examination and the Bayley Scales of Infant Development-III (BSID-III). NDI was defined as Gross Motor Function Classification System of >2 (moderate or severe cerebral palsy), BSID-III language or cognitive scores of <70, severe bilateral hearing impairment, and/or bilateral blindness.
resultsThe composite outcome, death or NDI, was obtained for 628 of 884 study infants (72%). The prevalence of this outcome was 44.4% (136/306) among controls (infants randomized to heart rate characteristics monitored but not displayed) and 38.9% (125/322) among infants randomized to heart rate characteristics monitoring displayed (relative risk, 0.87; 95% CI, 0.73-1.05; P = .17). Mortality was reduced from 32.0% (99/307) among controls to 24.8% (81/326) among monitoring displayed infants (relative risk, 0.75; 95% CI, 0.59 to 0.97; P = .028). The composite outcomes of death or severe CP and death or mildly low Bayley cognitive score occurred less frequently in the displayed group (P < .05).
conclusionsWe found no difference in the composite outcome of death or NDI for extremely preterm infants whose heart rate characteristics were and were not displayed during neonatal intensive care. Two outcomes that included mortality or a specific NDI were less frequent in the displayed group.
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