Evidence map›Paper›PMID 32033610›Full record

Trial reportReproductive biology and endocrinology : RB&E2020

Luteal phase stimulation versus follicular phase stimulation in poor ovarian responders: results of a randomized controlled trial.

Joaquín Llácer, Belén Moliner, Lydia Luque, Andrea Bernabéu, Belén Lledó, Juan Carlos Castillo, Jaime Guerrero, Jorge Ten, Rafael Bernabéu

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Reproductive biology and endocrinology : RB&E, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02625532 (Early Follicular Phase vs Lutheal Phase Ovarian Stimulation in Bologna Criteria IVF/ICSI Cycles), which is not on this map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02625532 naunknown statusnot on this map

Early Follicular Phase vs Lutheal Phase Ovarian Stimulation in Bologna Criteria IVF/ICSI Cycles: A Randomized Comparative Single Center Trial. LUTEAL Trial

TypeinterventionalSponsorInstituto BernabeuRan2015 to 2019Enrolled60ConditionsReproductive Techniques, AssistedArmsFollicular phase, Luteal phase
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Joaquín LlácerDepartment of Reproductive Medicine, Instituto Bernabeu, Av. Albufereta 31-37, 03016, Alicante, Spain. jllacer@institutobernabeu.com.ORCID http://orcid.org/0000-0002-8023-6528
Belén MolinerDepartment of Reproductive Medicine, Instituto Bernabeu, Av. Albufereta 31-37, 03016, Alicante, Spain.
Lydia LuqueDepartment of Reproductive Medicine, Instituto Bernabeu, Av. Albufereta 31-37, 03016, Alicante, Spain.
Andrea BernabéuDepartment of Reproductive Medicine, Instituto Bernabeu, Av. Albufereta 31-37, 03016, Alicante, Spain.
Belén LledóDepartment of Clinical Laboratory, Instituto Bernabeu, 03016, Alicante, Spain.
Juan Carlos CastilloDepartment of Reproductive Medicine, Instituto Bernabeu, Av. Albufereta 31-37, 03016, Alicante, Spain.
Jaime GuerreroDepartment of Reproductive Medicine, Instituto Bernabeu, Av. Albufereta 31-37, 03016, Alicante, Spain.
Jorge TenDepartment of Reproductive Medicine, Instituto Bernabeu, Av. Albufereta 31-37, 03016, Alicante, Spain.
Rafael BernabéuDepartment of Reproductive Medicine, Instituto Bernabeu, Av. Albufereta 31-37, 03016, Alicante, Spain.
Instituto Bernabeu · ES

Funding

Rafael Bernabeu Foundation -
6 · The paper itself

Abstract

backgroundIn young women with poor ovarian response, luteal-phase ovarian stimulation (LPOS) is a potential method for collecting competent oocytes. The aim of this study was to assess the efficacy of LPOS compared with follicular phase ovarian stimulation (FPOS) in young women with poor ovarian response (POR).

methodsThis single-center, prospective, randomized pilot study compared LPOS and FPOS in women with POR fulfilling Bologna criteria who underwent in vitro fertilization at the Instituto Bernabeu. The primary outcome was the number of metaphase II (MII) oocytes obtained by follicular puncture.

resultsSixty women were included in the study, with 27 women completing LPOS and 30 undergoing FPOS. There was no statistically significant difference in the number of MII oocytes obtained between the LPOS group and the FPOS group (2.1 ± 2.0 vs. 2.6 ± 2.2, p = 0.31). Length of stimulation was also similar in both groups (8.35 ± 2.8 vs. 8.15 ± 4.1 days, p = 0.69). Similarly, there was no significant difference in the follicle-stimulating hormone total dose, number of cumulus-oocyte complexes, survival rate, fertilization rate, or cancellation rate between groups. A significantly higher Ovarian Sensitivity Index was observed in the LPOS group versus the FPOS group (0.96 vs. 0.57, p = 0.037).

conclusionLPOS was comparable with FPOS in terms of efficacy and may improve ovarian responsiveness in young women with POR.

trial registrationClinicalTrials.gov identifier: NCT02625532; EudraCT identifier: 2015-003856-31.

Indexed as

AdultFemaleFertilization in VitroFollicular PhaseHumansLuteal PhaseOocyte RetrievalOvulation InductionPilot ProjectsProspective StudiesFollicular-phase ovarian stimulationLuteal-phase ovarian stimulationOvarian reservePoor ovarian respondersRandomized clinical trial

Identifiers

PMID32033610
PMCPMC7007665
OpenAlexW3006672074

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.