ArticleBMC neurology2020
Association between non-high-density lipoprotein cholesterol and haemorrhagic transformation in patients with acute ischaemic stroke.
Article in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Non-HDL-C, Symptomatic Intracranial Arterial Stenosis, and Recurrent Vascular Risk in Minor Stroke.Journal of atherosclerosis and thrombosis · 2025Article
- Association of atherogenic index of plasma with early-onset post-stroke depression: a prospective study.Frontiers in psychiatry · 2025Article
- Association between atherogenic index of plasma and post-stroke depression: a cross-sectional study.European journal of psychotraumatology · 2024Article
- Association Between the Atherogenic Index of Plasma and 90-Day Clinical Prognosis in Patients with Acute Pontine Infarction: A Single Center Study.International journal of general medicine · 2024Article
- Traditional and Non-Traditional Lipid Parameters in Relation to Parenchymal Hemorrhage Following Endovascular Treatment for Acute Ischemic Stroke in Anterior Circulation.Clinical interventions in aging · 2024Article
- Relationship between the cumulative exposure to atherogenic index of plasma and ischemic stroke: a retrospective cohort study.Cardiovascular diabetology · 2023Article
- Impact of lipid profiles on parenchymal hemorrhage and early outcome after mechanical thrombectomy.Annals of clinical and translational neurology · 2023Article
- Impact of Traditional and Non-Traditional Lipid Parameters on Outcomes after Intravenous Thrombolysis in Acute Ischemic Stroke.Journal of clinical medicine · 2022Article
- Association of Dilated Perivascular Spaces With Lipid Indices in Ischemic Stroke Patients.Cureus · 2022Article
- SWATH-MS for prospective identification of protein blood biomarkers of rtPA-associated intracranial hemorrhage in acute ischemic stroke: a pilot study.Scientific reports · 2021Article
- Predictors and Prognosis of Symptomatic Intracranial Hemorrhage in Acute Ischemic Stroke Patients Without Thrombolysis: Analysis of Data From the Chinese Acute Ischemic Stroke Treatment Outcome Registry.Frontiers in neurology · 2021Article
- Development and Validation of a Predictive Model for Spontaneous Hemorrhagic Transformation After Ischemic Stroke.Frontiers in neurology · 2021Article
- Prediction of Hemorrhagic Transformation After Ischemic Stroke: Development and Validation Study of a Novel Multi-biomarker Model.Frontiers in aging neuroscience · 2021Article
- Atherogenic Index of Plasma Predicts Outcomes in Acute Ischemic Stroke.Frontiers in neurology · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIt is unclear whether non-high-density lipoprotein cholesterol (Non-HDL-C) is associated with haemorrhagic transformation (HT) after acute ischaemic stroke (AIS). We aimed to explore the association between Non-HDL-C and HT, as well as compare the predictive values of Non-HDL-C and low-density lipoprotein cholesterol (LDL-C) for HT.
methodsWe consecutively enrolled AIS patients within 7 days of stroke onset. Participants were divided into four categories according to quartiles of Non-HDL-C. HT was assessed by follow-up brain imaging. We assessed the association between Non-HDL-C, LDL-C and HT in multivariate logistic regression analysis.
resultsA total of 2043 patients were included, among whom 232 were identified as HT. Compared with the highest quartiles, the first, second and third quartiles of Non-HDL-C were associated with increased risk of HT (adjusted odds ratios [ORs] 1.74 [95% confidence interval [CI] 1.09-2.78], 2.01[95% CI 1.26-3.20], and 1.76 [95% CI 1.10-2.83], respectively, P for trend = 0.024). Similar results were found for LDL-C. There was significant interaction between Non-HDL-C and age (P for interaction = 0.021). The addition of Non-HDL-C and LDL-C to conventional factors significantly improved predictive values [Non-HDL-C, net reclassification index (NRI) 0.24, 95%CI 0.17-0.31, P < 0.001; LDL-C, NRI 0.15, 95%CI 0.08-0.22, P = 0.03].
conclusionsLow Non-HDL-C was associated with increased risks of HT. In addition, Non-HDL-C has similar effects as LDL-C for predicting HT.
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