Evidence map›Paper›PMID 32033352›Full record

ArticleToxins2020

Isolation of an Anti-Tumour Disintegrin: Dabmaurin-1, a Peptide Lebein-1-Like, from

Florence Chalier, Laura Mugnier, Marion Tarbe, Soioulata Aboudou, Claude Villard, Hervé Kovacic, Didier Gigmes, Pascal Mansuelle, Harold de Pomyers, José Luis and 1 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Florence ChalierINP, Institut de Neurophysiopathologie; UMR 7051-CNRS & Aix-Marseille Université, Faculté de Pharmacie, 27 bd Jean Moulin, 13285 Marseille cedex 05, France.
Laura MugnierICR, Institut de Chimie Radicalaire ; UMR 7273-CNRS & Aix-Marseille Université - Faculté des Sciences de Saint Jérôme, Avenue Escadrille Normandie Niémen, 13397 Marseille Cedex 20, France.
Marion TarbeICR, Institut de Chimie Radicalaire ; UMR 7273-CNRS & Aix-Marseille Université - Faculté des Sciences de Saint Jérôme, Avenue Escadrille Normandie Niémen, 13397 Marseille Cedex 20, France.
Soioulata AboudouICR, Institut de Chimie Radicalaire ; UMR 7273-CNRS & Aix-Marseille Université - Faculté des Sciences de Saint Jérôme, Avenue Escadrille Normandie Niémen, 13397 Marseille Cedex 20, France.
Claude VillardINP, Institut de Neurophysiopathologie; UMR 7051-CNRS & Aix-Marseille Université, Faculté de Pharmacie, 27 bd Jean Moulin, 13285 Marseille cedex 05, France.
Hervé KovacicINP, Institut de Neurophysiopathologie; UMR 7051-CNRS & Aix-Marseille Université, Faculté de Pharmacie, 27 bd Jean Moulin, 13285 Marseille cedex 05, France.
Didier GigmesICR, Institut de Chimie Radicalaire ; UMR 7273-CNRS & Aix-Marseille Université - Faculté des Sciences de Saint Jérôme, Avenue Escadrille Normandie Niémen, 13397 Marseille Cedex 20, France.
Pascal MansuelleIMM (MaP), Institut de Microbiologie de la Méditerranée (Marseille Protéomique); FR 3479 - CNRS & Aix-Marseille Université, 31 Chemin Joseph Aiguier, 13009 Marseille, France.
Harold de PomyersLatoxan Laboratory, Z.A Auréats, 845 Avenue Pierre Brossolette, 26800 PORTES lès VALENCE, France.
José LuisINP, Institut de Neurophysiopathologie; UMR 7051-CNRS & Aix-Marseille Université, Faculté de Pharmacie, 27 bd Jean Moulin, 13285 Marseille cedex 05, France.
Kamel MabroukICR, Institut de Chimie Radicalaire ; UMR 7273-CNRS & Aix-Marseille Université - Faculté des Sciences de Saint Jérôme, Avenue Escadrille Normandie Niémen, 13397 Marseille Cedex 20, France.
Centre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the soft treatment of cancer tumours, consequent downregulation of the malignant tissue angiogenesis constitutes an efficient way to stifle tumour development and metastasis spreading. As angiogenesis requires integrin-promoting endothelial cell adhesion, migration, and vessel tube formation, integrins represent potential targets of new therapeutic anti-angiogenic agents. Our work is a contribution to the research of such therapeutic disintegrins in animal venoms. We report isolation of one peptide, named Dabmaurin-1, from the hemotoxic venom of snake

Indexed as

ViperidaeAmino Acid SequenceAngiogenesis InhibitorsAnimalsCell AdhesionCell LineCell MovementCell ProliferationCell SurvivalDisintegrinsDose-Response Relationship, DrugEndothelial CellsExtracellular MatrixHumansNeovascularization, PathologicViper VenomsAngiogenesis InhibitorsDisintegrinslebeinViper Venomsangiogenesisanti–angiogenic peptideanti–tumourcell adhesion moleculesdisintegrinendothelial cellsintegrinsnake venom

Identifiers

PMID32033352
PMCPMC7076848
OpenAlexW3005235505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.