ArticleBiomolecules2020
Anticancer Activity of Rutin and Its Combination with Ionic Liquids on Renal Cells.
Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- TransfersomILs: A Synergy to Boost the Skin Delivery of Hydroxycinnamic Acids.Pharmaceutics · 2026Article
- Anticancer activity and molecular docking of active ingredients from ethanolic extract of grapefruit peels against HepG2 cell.Scientific reports · 2026Article
- Polyphenol-Rich Wild Fruits of the Indian Himalayas as a Potential Nutraceutical Candidate for the Management of Endometriosis: A Review.Foods (Basel, Switzerland) · 2026Review
- Current State of Knowledge of the Anticancer Properties of Polyphenolic Compounds from Garlic (Molecules (Basel, Switzerland) · 2026Review
- The Therapeutic Potential ofMolecules (Basel, Switzerland) · 2025Article
- Box-Behnken Design Optimization of Green Extraction from Tomato Aerial Parts and Axillary Shoots for Enhanced Recovery of Rutin and Complementary Bioactive Compounds.Antioxidants (Basel, Switzerland) · 2025Article
- Natural Compounds in Cancer Therapy: Revealing the Role of Flavonoids in Renal Cell Carcinoma Treatment.Biomolecules · 2025Review
- Inorganic Element Identification and In Vitro Preliminary Evaluation of Three Types of Standardized Black Chokeberry Extracts Against Human Pulmonary Artery Endothelial Cells (HPAECs).Plants (Basel, Switzerland) · 2025Article
- Phytotoxicity, Cytotoxicity, and Antimicrobial Activity of Triethanolammonium Amino Acids Salts.Molecules (Basel, Switzerland) · 2025Article
- Insight into the time-dependent corrosion protection of mild steel by green ionic liquids: a combined electrochemical, surface, and computational study.RSC advances · 2025Article
- The potential role of rutin, a flavonoid, in the management of cancer through modulation of cell signaling pathways.Open life sciences · 2025Review
- Antitumor Effect of Butia odorata Hydroalcoholic Extract on C6 and U87MG Glioma Cell Lines: Impact on Redox Status and Inflammation Signaling.Neurochemical research · 2024Article
- Rutin suppresses the malignant biological behavior of gastric cancer cells through the Wnt/β-catenin pathway.Discover oncology · 2024Article
- Contemporary Speculations and Insightful Thoughts on Buckwheat-A Functional Pseudocereal as a Smart Biologically Active Supplement.Foods (Basel, Switzerland) · 2024Review
- Development of phenyllactic acid ionic liquids and evaluation of cytotoxicity to human cervical epithelial cells.RSC advances · 2024Article
- Highly Promiscuous Flavonoid Di-Molecules (Basel, Switzerland) · 2024Article
- Development of White Cabbage, Coffee, and Red Onion Extracts as Natural Phosphodiesterase-4B (PDE4B) Inhibitors for Cognitive Dysfunction:Advances in pharmacological and pharmaceutical sciences · 2024Article
- ULK1 Mediated Autophagy-Promoting Effects of Rutin-Loaded Chitosan Nanoparticles Contribute to the Activation of NF-κB Signaling Besides Inhibiting EMT in Hep3B Hepatoma Cells.International journal of nanomedicine · 2024Article
- A decade of advances in the study of buckwheat for organic farming and agroecology (2013-2023).Frontiers in plant science · 2024Review
- An Integrated Molecular Networking and Docking Approach to Characterize the Metabolome ofMetabolites · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The renal cell carcinoma (RCC) is the most common type of kidney cancer. Identifying novel and more effective therapies, while minimizing toxicity, continues to be fundamental in curtailing RCC. Rutin, a bioflavonoid widely found in nature, has shown promising anticancer properties, but with limited applicability due to its poor water solubility and pharmacokinetics. Thus, the potential anticancer effects of rutin toward a human renal cancer cell line (786-O), while considering its safety in Vero kidney cells, was assessed, as well as the applicability of ionic liquids (ILs) to improve drug delivery. Rutin (up to 50 µM) did not show relevant cytotoxic effects in Vero cells. However, in 786-O cells, a significant decrease in cell viability was already observed at 50 µM. Moreover, exposure to rutin caused a significant increase in the sub-G1 population of 786-O cells, reinforcing the possible anticancer activity of this biomolecule. Two choline-amino acid ILs, at non-toxic concentrations, enhanced rutin's solubility/loading while allowing the maintenance of rutin's anticancer effects. Globally, our findings suggest that rutin may have a beneficial impact against RCC and that its combination with ILs ensures that this poorly soluble drug is successfully incorporated into ILs-nanoparticles hybrid systems, allowing controlled drug delivery.
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Registered trials
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