Evidence map›Paper›PMID 32033146›Full record

ReviewCancers2020

Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells.

Kirti S Prabhu, Afsheen Raza, Thasni Karedath, Syed Shadab Raza, Hamna Fathima, Eiman I Ahmed, Shilpa Kuttikrishnan, Lubna Therachiyil, Michal Kulinski, Said Dermime and 3 more

Abstract readReview
In one paragraph

Review in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Review
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  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Cancer stem cells: a major culprit of intra-tumor heterogeneity.American journal of cancer research · 2021
    Review
  14. Review
  15. Review
  16. Review
  17. Long noncoding RNAs in osteosarcoma via various signaling pathways.Journal of clinical laboratory analysis · 2020
    Review
  18. Article
  19. Article
  20. Regulatory Networks of LncRNA MALAT-1 in Cancer.Cancer management and research · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kirti S PrabhuTranslational Research Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar.
Afsheen RazaNational Center for Cancer Care and Research, Hamad Medical Corporation, Doha 3050, Qatar.
Thasni KaredathSidra Medicine, Doha 26999, Qatar.
Syed Shadab RazaDepartment of Stem Cell Biology and Regenerative Medicine, Era University, Lucknow 226003, India.
Hamna FathimaTranslational Research Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar.
Eiman I AhmedTranslational Research Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar.
Shilpa KuttikrishnanTranslational Research Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar.
Lubna TherachiyilTranslational Research Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar.
Michal KulinskiTranslational Research Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar.
Said DermimeNational Center for Cancer Care and Research, Hamad Medical Corporation, Doha 3050, Qatar.
Kulsoom JunejoGeneral Surgery Department, Hamad General Hospital, Hamad Medical Corporation, Doha 3050, Qatar.
Martin SteinhoffTranslational Research Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar.
Shahab UddinTranslational Research Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar.

Funding

Hamad Medical Corporation 16354/16
6 · The paper itself

Abstract

Breast cancer is regarded as a heterogeneous and complicated disease that remains the prime focus in the domain of public health concern. Next-generation sequencing technologies provided a new perspective dimension to non-coding RNAs, which were initially considered to be transcriptional noise or a product generated from erroneous transcription. Even though understanding of biological and molecular functions of noncoding RNA remains enigmatic, researchers have established the pivotal role of these RNAs in governing a plethora of biological phenomena that includes cancer-associated cellular processes such as proliferation, invasion, migration, apoptosis, and stemness. In addition to this, the transmission of microRNAs and long non-coding RNAs was identified as a source of communication to breast cancer cells either locally or systemically. The present review provides in-depth information with an aim at discovering the fundamental potential of non-coding RNAs, by providing knowledge of biogenesis and functional roles of micro RNA and long non-coding RNAs in breast cancer and breast cancer stem cells, as either oncogenic drivers or tumor suppressors. Furthermore, non-coding RNAs and their potential role as diagnostic and therapeutic moieties have also been summarized.

Indexed as

biogenesisbreast cancer stem cellslong non-coding RNAmicroRNAtargets

Identifiers

PMID32033146
PMCPMC7072613

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.