Evidence map›Paper›PMID 32033079›Full record

ArticleMolecules (Basel, Switzerland)2020

Marine Microorganism-Derived Macrolactins Inhibit Inflammatory Mediator Effects in LPS-Induced Macrophage and Microglial Cells by Regulating BACH1 and HO-1/Nrf2 Signals through Inhibition of TLR4 Activation.

Eun-Nam Kim, Ming Gao, Hyukjae Choi, Gil-Saeng Jeong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Eun-Nam KimCollege of Pharmacy, Keimyung University, 1095 Dalgubeol-daero, Daegu 42601, Korea.
Ming GaoCollege of Pharmacy, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, Korea.
Hyukjae ChoiCollege of Pharmacy, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, Korea.ORCID 0000-0002-7707-4767
Gil-Saeng JeongCollege of Pharmacy, Keimyung University, 1095 Dalgubeol-daero, Daegu 42601, Korea.
Keimyung University · KRYeungnam University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, many natural products with unique structure and promising pharmacological potential have been reported from marine-derived microorganisms. The macrolactin A (MA), 15-

Indexed as

AnimalsAnti-Inflammatory AgentsAquatic OrganismsBacillusBasic-Leucine Zipper Transcription FactorsCell LineCyclooxygenase 2Enzyme ActivationHeme Oxygenase-1LipopolysaccharidesMacrolidesMacrophagesMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesMembrane ProteinsMiceAnti-Inflammatory AgentsBach1 protein, mouseBasic-Leucine Zipper Transcription FactorsCyclooxygenase 2Heme Oxygenase-1Hmox1 protein, mouseLipopolysaccharidesmacrolactin Amacrolactin FMacrolidesMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesMembrane ProteinsNfe2l2 protein, mouseNF-E2-Related Factor 2NF-kappa BNitric Oxide Synthase Type IIPtgs2 protein, mouseTlr4 protein, mouseToll-Like Receptor 4BTB Domain and CNC Homolog 1 (BACH1)heme oxygenase (HO)-1nuclear factor erythroid 2-related factor 2 (Nrf2)Toll-like receptor 4 (TLR4)

Identifiers

PMID32033079
PMCPMC7037854
OpenAlexW3005485884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.