ReviewAntioxidants (Basel, Switzerland)2020
Molecular Changes Induced by Oxidative Stress that Impair Human Sperm Motility.
Review in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
115 citing papers in PubMed, 3 syntheses or guidelines pooled it, 240 citations in OpenAlex.
- Global research trends on the impact of obesity on male infertility: a bibliometric analysis.Frontiers in nutrition · 2026Pooled it
- Exploring the link between periodontal disease and sperm quality: a comprehensive systematic review study.BMC oral health · 2025Pooled it
- Understanding the impact of valproate on male fertility: insights from preclinical and clinical meta-analysis.BMC pharmacology & toxicology · 2024Pooled it
- Proteomic Landscape of Spermatozoa Under Inflammatory and Oxidative Injury: Molecular Mechanisms and Clinical Translation.Antioxidants (Basel, Switzerland) · 2026Review
- Coenzyme Q10 supplementation enhances HSP70 gene expression and preserves mitochondrial function in cryopreserved Peranakan Ettawa goat spermatozoa.Veterinary world · 2026Article
- Impact of Environmental Conditions During IVF Laboratory Handling on Sperm Quality.International journal of molecular sciences · 2026Article
- Impact of A Fertility Diet on Male Reproductive Function: A 12-Week Randomized Clinical Trial in Idiopathic Infertility Patients.International journal of fertility & sterility · 2026Article
- Antioxidant Capacity of Seminal Plasma and Its Association with Semen Quality and Dietary Antioxidant Intake.Nutrients · 2026Article
- Article
- Oxidative Stress and Male Reproductive Health-First Edition.Antioxidants (Basel, Switzerland) · 2026Article
- Isoprostanes and Isofurans in Infertility and Assisted Reproduction: What Do We Know So Far?International journal of molecular sciences · 2026Review
- Targeting AMPK Networks for Male Reproductive Health: Mechanisms and Emerging Therapies.Cells · 2026Review
- Post-maceration storage temperature affects sperm quality and fertilization in sex-reversed rainbow trout.Scientific reports · 2026Article
- Oxidative Stress and Inflammatory Biomarkers in Male Infertility: A Narrative Review of Diagnostic Value and Clinical Integration.Diagnostics (Basel, Switzerland) · 2026Review
- Psychological Stress and Male Infertility: Oxidative Stress as the Common Downstream Pathway.Biomedicines · 2026Review
- Seminal Plasma and Extracellular Vesicles as Molecular Gatekeepers: Oxidative Stress, Endocrine Crosstalk, and Biomarker Discovery in Male Infertility.Current issues in molecular biology · 2026Review
- Dietary antioxidants and micronutrient status in varicocele-associated male infertility: oxidative stress-mediated effects on semen quality.Frontiers in nutrition · 2026Article
- Development and validation of a machine learning model for sperm DNA fragmentation rate in infertile men: a multicenter retrospective study.Frontiers in endocrinology · 2026Article
- Semenogelin I-derived peptide SgI-52 binds membrane Peroxiredoxin 6 and induces oxidative stress in asthenozoospermic sperm.Reproductive biology and endocrinology : RB&E · 2025Article
- Determination of the Antioxidant Capacity of Human Seminal Fluid Using a Fast and Accurate Electrochemical Approach.Antioxidants (Basel, Switzerland) · 2025Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A state of oxidative stress (OS) and the presence of reactive oxygen species (ROS) in the male reproductive tract are strongly correlated with infertility. While physiological levels of ROS are necessary for normal sperm functioning, elevated ROS production can overwhelm the cell's limited antioxidant defenses leading to dysfunction and loss of fertilizing potential. Among the deleterious pleiotropic impacts arising from OS, sperm motility appears to be particularly vulnerable. Here, we present a mechanistic account for how OS contributes to altered sperm motility profiles. In our model, it is suggested that the abundant polyunsaturated fatty acids (PUFAs) residing in the sperm membrane serve to sensitize the male germ cell to ROS attack by virtue of their ability to act as substrates for lipid peroxidation (LPO) cascades. Upon initiation, LPO leads to dramatic remodeling of the composition and biophysical properties of sperm membranes and, in the case of the mitochondria, this manifests in a dissipation of membrane potential, electron leakage, increased ROS production and reduced capacity for energy production. This situation is exacerbated by the production of cytotoxic LPO byproducts such as 4-hydroxynonenal, which dysregulate molecules associated with sperm bioenergetic pathways as well as the structural and signaling components of the motility apparatus. The impact of ROS also extends to lesions in the paternal genome, as is commonly seen in the defective spermatozoa of asthenozoospermic males. Concluding, the presence of OS in the male reproductive tract is strongly and positively correlated with reduced sperm motility and fertilizing potential, thus providing a rational target for the development of new therapeutic interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.