ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020
Associations of cigarette smoking with gray and white matter in the UK Biobank.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 64 citations in OpenAlex.
- Heterogeneous structural brain signatures of methamphetamine and ketamine use disorders revealed by normative modeling.Molecular psychiatry · 2026Article
- Stage-specific effects of early-life tobacco exposure on mental health, inflammation, and brain structure-function coupling.Translational psychiatry · 2026Article
- Identification of a miRNA signature for schizophrenia in plasma-derived extracellular vesicles.bioRxiv : the preprint server for biology · 2026Article
- Microstructural brain changes in Buerger's disease and smokers: a case-control study using diffusion tensor imaging.BMC medical imaging · 2026Article
- Tactile learning and memory deficits following cigarette and e-cigarette exposure: neural alterations in the barrel cortex and hippocampus.Cognitive processing · 2026Article
- Phenome-wide analysis of genetically imputed neuroimaging phenotypes reveals associations with psychiatric traits in a multi-ancestry cohort.medRxiv : the preprint server for health sciences · 2025Article
- Dose-Response Associations of Grip Strength and Gait Speed With Multidimensional Mental Health.Aging medicine (Milton (N.S.W)) · 2025Article
- The causal effect of smoking on psychiatric disorders: an examination of brain volume as a potential pathway.Psychological medicine · 2025Article
- Tobacco Smoking Functional Networks: A Whole-Brain Connectome Analysis in 24 539 Individuals.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Cerebrovascular health impacts processing speed through anterior white matter alterations: a UK biobank study.Scientific reports · 2025Article
- Latent profiles of modifiable dementia risk factors in later midlife: relationships with incident dementia, cognition, and neuroimaging outcomes.Molecular psychiatry · 2025Article
- Anterior and posterior cerebral white matter show different patterns of microstructural alterations in young adult smokers.Brain imaging and behavior · 2025Article
- Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation.Brain : a journal of neurology · 2024Article
- Alcohol, smoking, and brain structure: common or substance specific associations.medRxiv : the preprint server for health sciences · 2024Article
- Article
- Changes in metabolic hormones and trace elements in CSF in active smokers indicate oxidative damage to brain cells.Endocrine connections · 2024Article
- The interaction effects of age, APOE and common environmental risk factors on human brain structure.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Association of white matter hyperintensities with cognitive decline and neurodegeneration.Frontiers in aging neuroscience · 2024Article
- Investigating the Relationship Between Smoking Behavior and Global Brain Volume.Biological psychiatry global open science · 2024Article
- An augmented Mendelian randomization approach provides causality of brain imaging features on complex traits in a single biobank-scale dataset.PLoS genetics · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Cigarette smoking is associated with increased risk for myriad health consequences including cognitive decline and dementia, but research on the link between smoking and brain structure is nascent. In the current study, we assessed the relationship of cigarette smoking with gray matter (GM) and white matter (WM) in the UK Biobank, controlling for numerous confounding demographic and health variables. We used negative-binomial regression to model the association of cigarette smoking (having ever smoked regularly, cigarettes per day, and duration smoked) with GM and WM (GM N = 19,615; WM N = 17,760), adjusting for confounders. Ever smoked and duration were associated with smaller total GM volume. Ever smoked was associated with reduced volume of the right VIIIa cerebellum and elevated WM hyperintensity volume. Smoking duration was associated with reduced total WM volume. Regarding specific tracts, ever smoked was associated with reduced fractional anisotropy in the left cingulate gyrus part of the cingulum, left posterior thalamic radiation, and bilateral superior thalamic radiation, and increased mean diffusivity in the middle cerebellar peduncle, right medial lemniscus, bilateral posterior thalamic radiation, and bilateral superior thalamic radiation. This study identified significant associations of cigarette exposure with global measures of GM and WM, and select associations of ever smoked, but not cigarettes per day or duration, with specific GM and WM regions. By controlling for important sociodemographic and health confounders, such as alcohol use, this study identifies distinct associations between smoking and brain structure, highlighting potential mechanisms of risk for common neurological sequelae (e.g., dementia).
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