ArticleJournal of the American College of Surgeons2020
Oncologic Safety and Outcomes in Patients Undergoing Nipple-Sparing Mastectomy.
Article in Journal of the American College of Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- How to approach the deep inferior epigastric perforator flap revision for optimal aesthetics.Gland surgery · 2026Review
- Assessment of treatment outcomes in patients with breast cancer who underwent mastectomy and breast reconstruction with sparing of the areola-nipple complex - single-center analysis.Frontiers in oncology · 2026Article
- Nipple-Sparing Mastectomy and Infection Risk after Immediate Breast Reconstruction.Journal of the American College of Surgeons · 2025Article
- Effects of breast size on breast reconstruction in BRCA mutation carriers and genetic high-risk patients after bilateral mastectomy.Breast cancer (Tokyo, Japan) · 2025Article
- Underuse of Postoperative Radiation After Nipple-Sparing Mastectomy for Standard Radiation Indications.Advances in radiation oncology · 2024Article
- Positive Nipple Margins in Nipple-Sparing Mastectomy: Management of Nipples Containing Cancer or Atypia.Annals of surgical oncology · 2024Article
- Autogenous breast reconstruction for total mastectomies: a narrative review.Annals of translational medicine · 2024Review
- Inframammary versus Periareolar Incision: A Comparison of Early Complications in Nipple-sparing Mastectomy.Plastic and reconstructive surgery. Global open · 2023Article
- Robotic-Assisted Nipple Sparing Mastectomy.Seminars in plastic surgery · 2023Review
- Oncologic Safety of Nipple-Sparing Mastectomy for Breast Cancer in BRCA Gene Mutation Carriers: Outcomes at 70 Months Median Follow-Up.Annals of surgical oncology · 2023Article
- Nipple-Sparing Mastectomy After Neoadjuvant Chemotherapy: Definitive Results with a Long-Term Follow-Up Evaluation.Annals of surgical oncology · 2023Article
- Closed-Incision and Surrounding Soft Tissue Negative Pressure Dressings in Post-Mastectomy Pre-Pectoral Direct-to-Implant Breast Reconstruction: A Pilot Study.Plastic surgery (Oakville, Ont.) · 2022Article
- Oncological Outcomes of Nipple-Sparing Mastectomy in an Unselected Population Evaluated in a Single Center.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022Article
- Autologous Breast Reconstruction with Free Nipple-Areola Graft after Circumareolar (Skin Reducing) Mastectomy.Journal of personalized medicine · 2022Article
- The Language of Implant-based Breast Reconstruction: Can We Do Better?Plastic and reconstructive surgery. Global open · 2022Article
- Health-Related Quality of Life After Nipple-Sparing Mastectomy: Results From the INSPIRE Registry.Annals of surgical oncology · 2022Article
- Outcome Analysis Depending on the Different Types of Incision following Immediate Breast Reconstruction.The breast journal · 2022Article
- Risk-reducing surgery inTranslational breast cancer research : a journal focusing on translational research in breast cancer · 2022Article
- Two-Stage Versus One-Stage Nipple-Sparing Mastectomy: Timing of Surgery Prevents Nipple Loss.Annals of surgical oncology · 2021Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNipple-sparing mastectomy (NSM) is an alternative to skin-sparing mastectomy in appropriately selected patients. The aim of this study was to review our experience with NSM and to evaluate for oncologic safety. STUDY
designPatients who underwent NSM at our institution from September 2008 through August 2017 were identified after IRB approval. Data included patient age, tobacco use, tumor size, hormone receptor status, lymph node status, radiation and chemotherapy use, incision type, and reconstruction type. Statistical analyses were performed using ANOVA and chi-square tests.
resultsThere were 322 patients who underwent 588 NSM (83% bilateral, 17% unilateral), including 399 (68%) for malignancy (Stage 0 [27%], I [44%], II [25%] and III [4%]). The overall rate of wound complication was 18.9%. Tobacco use increased complication (37.5% vs 16.3%, p < 0.001), as did adjuvant radiation therapy (31.4% vs 17.4%, p = 0.014). Patients with lymph node involvement and larger tumor size had a higher rate of complication (31.3% vs 17.2%, p = 0.016). Patients undergoing circumareolar incisions had a higher rate of complication than those undergoing lateral radial, inframammary fold, or curvilinear incisions (43.5% vs 17.4% vs 17.4% vs 14.3%, respectively, p = 0.018). Six (1%) local chest wall recurrences occurred during the follow-up period, none of which involved the nipple-areolar complex. Four patients (1%) suffered a distant recurrence.
conclusionsMost NSM performed at our institution are in patients with malignancy. The oncologic safety is confirmed by the low locoregional recurrence rate. Tobacco use and adjuvant radiation therapy remain the most significant risk factors for complication, highlighting the need for careful patient selection and patient counseling regarding modifiable risk factors and expected outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.