Evidence map›Paper›PMID 32032547›Full record

ArticleDevelopmental cell2020

Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement.

Helen K Matthews, Sushila Ganguli, Katarzyna Plak, Anna V Taubenberger, Zaw Win, Max Williamson, Matthieu Piel, Jochen Guck, Buzz Baum

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 101 citations in OpenAlex.

  1. Article
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  8. RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  9. Article
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  15. Focus on mechano-immunology: new direction in cancer treatment.International journal of surgery (London, England) · 2025
    Review
  16. Article
  17. The Role of the Swollen State in Cell Proliferation.The Journal of membrane biology · 2025
    Review
  18. Article
  19. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Helen K MatthewsMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address: h.matthews@ucl.ac.uk.
Sushila GanguliMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
Katarzyna PlakMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK; Biotechnology Center, Technische Universität Dresden, Tatzberg 47/49, 01307 Dresden, Germany.
Anna V TaubenbergerBiotechnology Center, Technische Universität Dresden, Tatzberg 47/49, 01307 Dresden, Germany.
Zaw WinMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Max WilliamsonMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
Matthieu PielInstitut Curie and Institut Pierre Gilles de Gennes, PSL Research University, CNRS, UMR 144, Paris, France.
Jochen GuckBiotechnology Center, Technische Universität Dresden, Tatzberg 47/49, 01307 Dresden, Germany; Max Planck Institute for the Science of Light & Max-Planck-Zentrum für Physik und Medizin, Staudtstraße 2, 91058 Erlangen, Germany.
Buzz BaumMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Institute for the Physics of Living Systems, University College London, London WC1E 6BT, UK. Electronic address: b.baum@ucl.ac.uk.
MRC Laboratory for Molecular Cell Biology · GBThe Francis Crick Institute · GBCentre National de la Recherche Scientifique · FRMax Planck Institute for the Science of Light · DETechnische Universität Dresden · DE

Funding

Biotechnology and Biological Sciences Research Council BB/R009732/1Cancer Research UK 17343Cancer Research UK 23335Cancer Research UK 28276Cancer Research UK 5369923Cancer Research UK 9786Cancer Research UK C1529/A17343Cancer Research UK C1529/A23335Medical Research Council MC_CF12266
6 · The paper itself

Abstract

To divide in a tissue, both normal and cancer cells become spherical and mechanically stiffen as they enter mitosis. We investigated the effect of oncogene activation on this process in normal epithelial cells. We found that short-term induction of oncogenic Ras

Indexed as

Cell ShapeMAP Kinase Signaling SystemMitosisStress, MechanicalCell LineChromosome SegregationHumansras ProteinsSpindle Apparatusras Proteinsactincancercell confinementcell mechanicsERKMAPK signalingMEKmitosismitotic roundingRas

Identifiers

PMID32032547
PMCPMC7063569
OpenAlexW3004958779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.