Evidence map›Paper›PMID 32032511›Full record

ArticleMolecular cell2020

Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma.

Marie R Webster, Mitchell E Fane, Gretchen M Alicea, Subhasree Basu, Andrew V Kossenkov, Gloria E Marino, Stephen M Douglass, Amanpreet Kaur, Brett L Ecker, Keerthana Gnanapradeepan and 22 more

Abstract readPublished Erratum
In one paragraph

Article in Molecular cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. p53 Family in Resistance to Targeted Therapy of Melanoma.International journal of molecular sciences · 2022
    Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors.

Marie R Webster
Mitchell E Fane
Gretchen M Alicea
Subhasree Basu
Andrew V Kossenkov
Gloria E Marino
Stephen M Douglass
Amanpreet Kaur
Brett L Ecker
Keerthana Gnanapradeepan
Abibatou Ndoye
Curtis Kugel
Alexander Valiga
Jessica Palmer
Qin Liu
Xiaowei Xu
Jessicamarie Morris
Xiangfan Yin
Hong Wu
Wei Xu
Cathy Zheng
Giorgos C Karakousis
Ravi K Amaravadi
Tara C Mitchell
Filipe V Almeida
Min Xiao
Vito W Rebecca
Ying-Jie Wang
Lynn M Schuchter
Meenhard Herlyn
Maureen E Murphy
Ashani T Weeraratna

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
Targeting the MAP and PI3 Kinase Pathways in MelanomaP01CA114046 · NCI · WISTAR INSTITUTE · PI WEERARATNA, ASHANI T · 2008 to 2023
$37.1M
Targeted Combination Therapy for MelanomaP50CA174523 · NCI · WISTAR INSTITUTE · PI HERLYN, MEENHARD F · 2014 to 2018
$11.1M
Functional Analysis of p53 Polymorphic Variants - Diversity SupplementR01CA102184 · NCI · WISTAR INSTITUTE · PI Maureen E. Murphy · 2005 to 2026
$7.4M
A plasticity and reprogramming paradigm for therapy resistance at the single cell levelU01CA227550 · NCI · UNIVERSITY OF PENNSYLVANIA · PI RADHAKRISHNAN, RAVI, RAJ, ARJUN · 2018 to 2022
$3.3M
An integrated approach to melanoma metastasis and therapy resistance: effects of age-related changes in the ECM and the biomechanics of the skinR01CA232256 · NCI · WISTAR INSTITUTE · PI CUKIERMAN, EDNA, RAJ, ARJUN · 2019 to 2023
$3.0M
Promotion of tumor invasion and pseudosenescence by the aging microenvironmentR01CA174746 · NCI · WISTAR INSTITUTE · PI WEERARATNA, ASHANI T · 2014 to 2018
$2.1M
Effect of the aged microenvironment on tumor dormancyR01CA207935 · NCI · WISTAR INSTITUTE · PI WEERARATNA, ASHANI T · 2017 to 2021
$2.0M
Integrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center LevelR50CA211199 · NCI · WISTAR INSTITUTE · PI Andrew V Kossenkov · 2016 to 2026
$1.6M
Histone modifications regulating phenotype plasticity: Role of non-canonical Wnt signalingR00CA208012 · NCI · LANKENAU INSTITUTE FOR MEDICAL RESEARCH · PI WEBSTER, MARIE RUTH · 2019 to 2021
$744k
Histone modifications regulating phenotype plasticity: Role of non-canonical Wnt signalingK99CA208012 · NCI · WISTAR INSTITUTE · PI WEBSTER, MARIE RUTH · 2016 to 2017
$228k
NCI NIH HHS K99 CA208012NCI NIH HHS P01 CA114046NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA010815NCI NIH HHS P50 CA174523NCI NIH HHS R00 CA208012NCI NIH HHS R01 CA102184NCI NIH HHS R01 CA174746NCI NIH HHS R01 CA207935NCI NIH HHS R01 CA232256NCI NIH HHS R50 CA211199NCI NIH HHS U01 CA227550
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID32032511
PMCPMC7441646

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.