Evidence map›Paper›PMID 32031879›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2020

Dietary Modification and Breast Cancer Mortality: Long-Term Follow-Up of the Women's Health Initiative Randomized Trial.

Rowan T Chlebowski, Aaron K Aragaki, Garnet L Anderson, Kathy Pan, Marian L Neuhouser, JoAnn E Manson, Cynthia A Thomson, Yasmin Mossavar-Rahmani, Dorothy S Lane, Karen C Johnson and 7 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 4 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 4 syntheses or guidelines pooled it, 210 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Low-Fat Dietary Modification and Risk of Ductal CarcinomaCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Trial
  11. Article
  12. Observational
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 1 country.

Rowan T ChlebowskiLos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA.
Aaron K AragakiDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
Garnet L AndersonDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
Kathy PanLos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA.
Marian L NeuhouserDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
JoAnn E MansonBrigham and Women's Hospital, Harvard Medical School, Boston, MA.
Cynthia A ThomsonDepartment of Nutritional Sciences, University of Arizona, Tucson, AZ.
Yasmin Mossavar-RahmaniDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
Dorothy S LaneDepartment of Family, Population and Preventive Medicine, Stony Brook University School of Medicine, Stony Brook, NY.
Karen C JohnsonDepartments of Preventive Medicine and Medicine, University of Tennessee, Memphis, TN.
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY.
Linda SnetselaarCollege of Public Health, University of Iowa, Iowa City, IA.
Thomas E RohanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
Juhua LuoDepartment of Epidemiology and Biostatistics, Indiana University, Bloomington, IN.
Ana BaracMedStar Heart and Vascular Institute, Georgetown University, Washington, DC.
Ross L PrenticeDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
Women’s Health Initiative
Fred Hutch Cancer Center · USAlbert Einstein College of Medicine · USHarbor–UCLA Medical Center · USBrigham and Women's Hospital · USGeorgetown University · USIndiana University Bloomington · USStony Brook University · USUniversity at Buffalo, State University of New York · USUniversity of Arizona · USUniversity of Iowa · USUniversity of Tennessee Health Science Center · US

Funding

WOMENS HEALTH INITIATIVE-N01WH22110N01WH022110 · WH · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ROSS, PRENTICE · 1992 to 2006
$1.2M
WHI NIH HHS N01 WH022110
6 · The paper itself

Abstract

purposeObservational studies of dietary fat intake and breast cancer have reported inconsistent findings. This topic was addressed in additional analyses of the Women's Health Initiative (WHI) Dietary Modification (DM) clinical trial that evaluated a low-fat dietary pattern influence on breast cancer incidence.

methodsIn the WHI DM trial, 48,835 postmenopausal women, ages 50-79 years, with no prior breast cancer, and a dietary fat intake of ≥ 32% of energy were randomly assigned at 40 US centers to a usual diet comparison group (60%) or dietary intervention group (40%). The goals were to reduce fat intake to 20% of energy and increase vegetable, fruit, and grain intake. Breast cancers were confirmed after central medical record review and serial National Death Index linkages to enhance mortality findings.

resultsDuring 8.5 years of dietary intervention, breast cancer incidence and deaths as a result of breast cancer were nonsignificantly lower in the intervention group, while deaths after breast cancer were statistically significantly lower both during intervention and through a 16.1-year (median) follow-up. Now, after a long-term, cumulative 19.6-year (median) follow-up, the significant reduction in deaths after breast cancer persists (359 [0.12%]

conclusionAdoption of a low-fat dietary pattern associated with increased vegetable, fruit, and grain intake, demonstrably achievable by many, may reduce the risk of death as a result of breast cancer in postmenopausal women.

Indexed as

Diet, Fat-RestrictedPostmenopauseAgedBreast NeoplasmsDietary FatsFemaleFollow-Up StudiesHumansIncidenceKaplan-Meier EstimateMiddle AgedOutcome Assessment, Health CareProportional Hazards ModelsRisk FactorsSurvival RateWomen's HealthDietary Fats

Identifiers

PMID32031879
PMCPMC7193750
OpenAlexW3004869595

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.