Evidence map›Paper›PMID 32031876›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2020

Nonmyeloablative Alternative Donor Transplantation for Hodgkin and Non-Hodgkin Lymphoma: From the LWP-EBMT, Eurocord, and CIBMTR.

Giancarlo Fatobene, Vanderson Rocha, Andrew St Martin, Mehdi Hamadani, Stephen Robinson, Asad Bashey, Ariane Boumendil, Claudio Brunstein, Luca Castagna, Alida Dominietto and 17 more

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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  10. In 2022, which is preferred: haploidentical or cord transplant?Hematology. American Society of Hematology. Education Program · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 20 institutions in 8 countries.

Giancarlo FatobeneHospital das Clínicas and LIM31, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Vanderson RochaHospital das Clínicas and LIM31, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Andrew St MartinCenter for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI.
Mehdi HamadaniCenter for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI.
Stephen RobinsonUniversity Hospitals Bristol National Health Service (NHS) Foundation Trust, Bristol, United Kingdom.
Asad BasheyThe Blood and Marrow Transplant Program, Northside Hospital, Atlanta, GA.
Ariane BoumendilEuropean Society for Blood and Marrow Transplantation Paris Study Office/European Center for Biostatistical and Epidemiological Evaluation in Hematopoietic Cell Therapy, Paris, France.
Claudio BrunsteinUniversity of Minnesota Medical Center, Minneapolis, MN.
Luca CastagnaIstituto Clinico Humanitas, Rozzano Milano, Italy.
Alida DominiettoIRCCS Ospedale Policlinico San Martino, Genova, Italy.
Hervé FinelEuropean Society for Blood and Marrow Transplantation Paris Study Office/European Center for Biostatistical and Epidemiological Evaluation in Hematopoietic Cell Therapy, Paris, France.
Yves ChalandonDivision of Hematology, Hôpitaux Universitaires of Geneva, Faculty of Medicine, University of Geneva, Geneva and Swiss Cancer Center Leman, Switzerland.
Chantal KenzeyEurocord, Université de Paris, Institut de Recherche de Saint-Louis (IRSL) EA3518, Paris, France.
Mohamed Kharfan-DabajaDivision of Hematology-Oncology and Blood and Marrow Transplantation Program, Mayo Clinic, Jacksonville, FL.
Hélène Labussière-WalletHospices Civils de Lyon, Centre Hospitalier Lyon Sud, Lyon, France.
Jose M MoraledaHospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
Rocco PastanoEuropean Institute of Oncology, Milano, Italy.
Miguel-Angel PeralesMemorial Sloan Kettering Cancer Center, New York, NY.
Hanadi Rafii El AyoubiEurocord, Université de Paris, Institut de Recherche de Saint-Louis (IRSL) EA3518, Paris, France.
Annalisa RuggeriDepartment of Pediatric Hematology and Oncology, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Pediatrico Bambino Gesù, Roma, Italy.
Anna SuredaClinical Hematology Department, Institut Català d'Oncxologia - Hospitalet, IDIBELL, Universitat de Barcelona, Barcelona, Spain.
Fernanda VoltEurocord, Université de Paris, Institut de Recherche de Saint-Louis (IRSL) EA3518, Paris, France.
Ibrahim Yakoub-AghaCHU de Lille, LIRIC, INSERM U995, Université de Lille, Lille, France.
Mei-Jie ZhangCenter for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI.
Eliane GluckmanEurocord, Université de Paris, Institut de Recherche de Saint-Louis (IRSL) EA3518, Paris, France.
Silvia MontotoDepartment of Haemato-Oncology, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom.
Mary EapenCenter for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI.
Medical College of Wisconsin · USEuropean Society for Blood and Marrow Transplantation · FRBambino Gesù Children's Hospital · ITChurchill Hospital · GBEuropean Institute of Oncology · ITHospices Civils de Lyon · FRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRHospital Universitario Virgen de la Arrixaca · ESHumanitas University · ITInserm · FRInstitut d'Investigació Biomédica de Bellvitge · ESMayo Clinic in Florida · USMemorial Sloan Kettering Cancer Center · USNational Health Service · GBNorthside Hospital · USOspedale Policlinico San Martino · ITScientific Centre of Monaco · MCSt Bartholomew's Hospital · GBUniversity of Geneva · CHUniversity of Minnesota Medical Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
Easy-to-read Informed Consent for HCT Clinical TrialsU10HL069294 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HOROWITZ, MARY MARESCA · 2011 to 2016
$43.8M
NCI NIH HHS P30 CA008748NCI NIH HHS U24 CA076518NHLBI NIH HHS U10 HL069294
6 · The paper itself

Abstract

purposeTo compare the outcomes of patients with Hodgkin or non-Hodgkin lymphoma undergoing nonmyeloablative haploidentical or unrelated cord blood (UCB) hematopoietic cell transplantation. PATIENTS AND

methodsWe retrospectively studied 740 patients with Hodgkin lymphoma (n = 283, 38%) and non-Hodgkin lymphoma (n = 457, 62%) age 18-75 years who received transplantations from 2009 to 2016. Data were reported to the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation, Eurocord, or Center for International Blood and Marrow Transplant Research. Of the 526 patients who received haploidentical transplantation, 68% received bone marrow and 32% received peripheral blood. All patients received a uniform transplantation conditioning regimen (2 Gy of total-body irradiation, cyclophosphamide, and fludarabine) and graft-versus-host disease prophylaxis (calcineurin inhibitor and mycophenolate). In addition, patients who received a haploidentical transplantation received posttransplantation cyclophosphamide.

resultsCompared with haploidentical bone marrow and peripheral-blood transplantations and adjusted for age, lymphoma subtype, and disease status, survival was lower after UCB transplantation (hazard ratio [HR], 1.55;

conclusionWhen considering HLA-mismatched transplantation for Hodgkin or non-Hodgkin lymphoma, the data support haploidentical related donor transplantation over UCB transplantation.

Identifiers

PMID32031876
PMCPMC7213591
OpenAlexW3005305777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.