Evidence map›Paper›PMID 32031519›Full record

ArticleParasite (Paris, France)2020

Serological diagnosis of Toxoplasma gondii: analysis of false-positive IgG results and implications.

Loïc Simon, Judith Fillaux, Aurélie Guigon, Rose-Anne Lavergne, Odile Villard, Isabelle Villena, Pierre Marty, Christelle Pomares, Toxoplasma p35 Study Group

Open access · goldAbstract read
In one paragraph

Article in Parasite (Paris, France), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Seroprevalence ofPathogens (Basel, Switzerland) · 2024
    Article
  8. Identification of novel biomarkers for anti-Frontiers in microbiology · 2024
    Article
  9. Heliyon · 2023
    Review
  10. Review
  11. Serological diagnosis of toxoplasmosis in pregnancy: comparison between a manual commercial ELISA assay and the automated VIDASEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023
    Article
  12. Article
  13. Article
  14. Identification of Oocyst-DrivenMicroorganisms · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Loïc SimonService de Parasitologie-Mycologie, CHU de Nice, Université Côte d'Azur, 06202 Nice, France - Inserm U1065, C3M, 06204 Nice, France.ORCID 0000-0001-5583-1272
Judith FillauxService de Parasitologie-Mycologie, CHU de Toulouse, 31300 Toulouse, France - PharmaDev, IRD UMR 152, Université de Toulouse, 31062 Toulouse, France.ORCID 0000-0002-5277-189X
Aurélie GuigonService de Microbiologie, Hôpital La Source, CHR d'Orléans, 45100 Orléans, France.
Rose-Anne LavergneParasitologie-Mycologie, CHU de Nantes, 44093 Nantes, France - Université de Nantes, Nantes Atlantique Universités, EA1155-IICiMed, Institut de Recherche en Santé 2, 44200 Nantes, France.
Odile VillardInstitut de Parasitologie et de Pathologie Tropicale, EA 7292, Fédération de Médecine Translationnelle, Université de Strasbourg, 67000 Strasbourg, France.
Isabelle VillenaEA7510, ESCAPE, Laboratoire de Parasitologie-Mycologie, Université de Reims Champagne-Ardenne, SFR Cap Santé FED 4231, 51096 Reims, France.ORCID 0000-0002-7415-4198
Pierre MartyService de Parasitologie-Mycologie, CHU de Nice, Université Côte d'Azur, 06202 Nice, France - Inserm U1065, C3M, 06204 Nice, France.
Christelle PomaresService de Parasitologie-Mycologie, CHU de Nice, Université Côte d'Azur, 06202 Nice, France - Inserm U1065, C3M, 06204 Nice, France.ORCID 0000-0002-6192-3293
Toxoplasma p35 Study Group
Inserm · FRCentre Hospitalier Universitaire de Nantes · FRCentre Hospitalier Universitaire de Reims · FRCentre hospitalier universitaire d'Orléans · FRUniversité de Strasbourg · FRUniversité Toulouse III - Paul Sabatier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary infection by Toxoplasma gondii in pregnant women can result in serious outcomes for the foetus. A false-positive IgG result during pregnancy can lead to a misdiagnosis of past infection and to stopping preventive measures. We collected 189 sera with positive Architect

resultsThe bands GRA8 and/or GRA7 were positive for 148 samples (78.3%). GRA8 was the most frequent band, appearing in 133 patterns (70.4%), whereas GRA7 was present for 49 samples (25.9%). Of the 81 samples tested with LDBio

conclusionsThe Architect

Indexed as

AdolescentAdultAgedAged, 80 and overAntibodies, ProtozoanChildChild, PreschoolCross ReactionsFalse Positive ReactionsFemaleHumansImmunoglobulin GInfantMaleMiddle AgedReagent Kits, DiagnosticAntibodies, ProtozoanImmunoglobulin GReagent Kits, DiagnosticArchitectFalse-positiveIgGSerologyToxoplasma gondiiToxoplasmosis

Identifiers

PMID32031519
PMCPMC7006501
OpenAlexW3005057619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.