ReviewDeutsches Arzteblatt international2020
In Vitro Fertilization Technology and Child Health.
Review in Deutsches Arzteblatt international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Toward global reproductive justice: a universal framework for evaluating equity and autonomy in in-vitro fertilization policies.Reproductive health · 2025Pooled it
- Successful assisted reproduction treatment and its psychological outcomes for parents and children: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2025Pooled it
- Crosstalk between H3K4me3 and oxidative stress is a potential target for the improvement of ART-derived embryos.Nature communications · 2025Article
- Review
- Whole-transcriptome sequencing reveals the effects of acupuncture on early embryos post-IVF-ET in poor ovarian response.Journal of ovarian research · 2025Article
- Neonatal Health Following IVF: Own Versus Donor Material in Singleton and Multiple Pregnancies.Life (Basel, Switzerland) · 2025Article
- Vascular Health in Adults Born After Using Assisted Reproductive Technologies.Pediatric cardiology · 2024Article
- Safety profiles of offspring born from early-follicular long-acting GnRH agonist protocol and daily mid-luteal GnRH agonist protocol: a retrospective study.BMC pregnancy and childbirth · 2024Article
- Review
- Article
- Childhood growth of singletons conceived following intracytoplasmic sperm injection - irrelevance of gonadotropin stimulation.Frontiers in reproductive health · 2024Article
- Fertility treatment increases the risk of preterm birth independent of multiple gestations.F&S reports · 2023Article
- Eclampsia,Translational pediatrics · 2023Article
- Autologous Human Mesenchymal Stem Cell-Based Therapy in Infertility: New Strategies and Future Perspectives.Biology · 2023Review
- Receipt of COVID-19 vaccine in preterm-born children aged 3-7 in China.Frontiers in public health · 2023Article
- Subjects Conceived through Assisted Reproductive Technologies Display Normal Arterial Stiffness.Diagnostics (Basel, Switzerland) · 2022Article
- Polygenic risk score for embryo selection-not ready for prime time.Human reproduction (Oxford, England) · 2022Article
- Families formed through assisted reproductive technology: Causes, experiences, and consequences in an international context.Reproductive biomedicine & society online · 2022Article
- Can Time-Lapse Incubation and Monitoring Be Beneficial to Assisted Reproduction Technology Outcomes? A Randomized Controlled Trial Using Day 3 Double Embryo Transfer.Frontiers in physiology · 2021Article
- Perinatal and neonatal outcomes of pregnancies after early rescue intracytoplasmic sperm injection in women with primary infertility compared with conventional intracytoplasmic sperm injection: a retrospective 6-year study.BMC pregnancy and childbirth · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundJust under 3% of children in Germany, and approximately 6% of children in some other countries, such as Denmark, are now being conceived with the aid of in vitro fertilization (IVF) technology. Alongside the increased risk of organ malformation, there is now evidence for functional abnormalities due to epigenetic modifications.
methodsThis review is based on pertinent publications retrieved by a literature search on currently known associations of IVF therapy with malformations and functional abnormalities. The potential implications for the treatment of infertility are discussed.
resultsThe risk of congenital malformations is approximately one-third higher in children conceived with the aid of IVF technology than in other children; specifically, there is an odds ratio (OR) of 1.29 (95% confidence interval, [1.03; 1.60]) for cardiac malformations, and there is a relative risk (RR) of 1.35 ([1.12; 1.64]) for musculo- skeletal malformations and 1.58 ([1.28; 1.94]) for genitourinary malformations. The risks of preterm birth and low birth weight are, respectively, 1.7 and 1.5 times higher in IVF singleton pregnancies than in non-IVF pregnancies. Cardiovascular changes are the main type of functional disturbance. Some of the risks associated with IVF have decreased in recent years. An association has been revealed between cardiovascular abnormalities and epigenetic modifications; the causes are thought to include not only maternal and paternal factors, but also the IVF techniques that are used. A modification of IVF therapies might lower the risks, but might also lower the success rate.
conclusionFor the well-being of the children to be conceived, IVF therapy should hat cannot be treated by any other means, as the precise causes of the risks of IVF to child health are unclear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.