Evidence map›Paper›PMID 32030822›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2020

Improving Tumor-to-Background Contrast through Hydrophilic Tetrazines: The Construction of

Huijuan Feng, He Zhang, Mengzhe Wang, Raghu Vannam, Hui Wang, Xuefeng Yan, Wei Ouyang, Xinqiao Jia, Joseph M Fox, Zibo Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Synthesis, preclinical assessment, and first-in-human study of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  3. Review
  4. Review
  5. Radionuclide-based theranostics - a promising strategy for lung cancer.European journal of nuclear medicine and molecular imaging · 2023
    Review
  6. Review
  7. Expression of neurotensin receptor-1 (NTSBreast cancer research and treatment · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Huijuan FengDepartment of Nuclear Medicine, ZhuJiang Hospital of Southern Medical University, Guangzhou, Guangdong, 510280, P. R. China.
He ZhangDepartment of Material Science and Engineering, University of Delaware, Newark, Delaware, 19716, USA.
Mengzhe WangDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.
Raghu VannamBrown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, 19716, USA.
Hui WangDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.
Xuefeng YanDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.
Wei OuyangDepartment of Nuclear Medicine, ZhuJiang Hospital of Southern Medical University, Guangzhou, Guangdong, 510280, P. R. China.
Xinqiao JiaDepartment of Material Science and Engineering, University of Delaware, Newark, Delaware, 19716, USA.
Joseph M FoxBrown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, 19716, USA.
Zibo LiDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.ORCID http://orcid.org/0000-0002-1063-0298
University of North Carolina at Chapel Hill · USUniversity of Delaware · USZhujiang Hospital · CN

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI SCHMITZ, KARL ROBERT · 2014 to 2024
$26.8M
Pilot Research Subproject ProgramP30GM110758 · NIGMS · UNIVERSITY OF DELAWARE · PI PATEL, SANDEEP · 2014 to 2018
$5.8M
Toolkit for Fast, Multipurpose and Inducible Bioorthogonal ChemistryR01GM132460 · NIGMS · UNIVERSITY OF DELAWARE · PI JOSEPH M FOX · 2019 to 2026
$4.2M
The Tetrazine Ligation for Efficient 18F Labeling and Pretargeted Imaging/Radiotherapy of CancerR01EB014354 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FOX, JOSEPH M, LI, ZIBO · 2013 to 2016
$1.4M
Small Animal PET/CT for Preclinical Imaging ResearchS10OD023611 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, ZIBO · 2017 to 2017
$835k
Q-Exactive Orbitrap LC-MC/MS SystemS10OD016267 · OD · UNIVERSITY OF DELAWARE · PI JOHNSTON, MURRAY V · 2013 to 2013
$573k
High Performance Digital NMR SpectrometerS10RR026962 · NCRR · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2010 to 2010
$500k
GM132460National Science Foundation CHE-0840401 CHE-1229234 CHE-1726291NCI NIH HHS P30 CA016086NCI NIH HHS P30-CA016086-35-37NCRR NIH HHS S10 RR026962NIBIB NIH HHS 5R01EB014354NIBIB NIH HHS R01 EB014354NIGMS NIH HHS P20 GM104316NIGMS NIH HHS P30 GM110758NIGMS NIH HHS R01 GM132460NIH HHS P20GM104316, P30GM110758, S10RR026962, S10OD016267, and 1S10OD023611NIH HHS S10 OD016267NIH HHS S10 OD023611UNC Radiology Department and the BRIC
6 · The paper itself

Abstract

Bioorthogonal reactions have been widely used in the biomedical field.

Indexed as

CarcinomaCarcinoma, Non-Small-Cell LungCell Line, TumorCycloaddition ReactionFluorine RadioisotopesHeterocyclic CompoundsHumansPositron-Emission TomographyFluorine-18Fluorine RadioisotopesHeterocyclic Compoundsmedicinal chemistryneurotensinnon-small cell lung carcinomaPETtetrazine

Identifiers

PMID32030822
PMCPMC7764167
OpenAlexW3004437356

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.