Evidence map›Paper›PMID 32030554›Full record

ArticleJournal of assisted reproduction and genetics2020

The use of autologous platelet-rich plasma (PRP) versus no intervention in women with low ovarian reserve undergoing fertility treatment: a non-randomized interventional study.

P Melo, C Navarro, C Jones, K Coward, L Coleman

3 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 53 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 5 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05279560 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

The Efficacy and Safety of Intra-ovarian PRP Injection Within a Prospective, Single-blinded, Placebo-controlled, Randomized, Clinical Superiority Trial in Subjects With Low Ovarian Reserve/Expected Poor Ovarian Response

TypeinterventionalSponsorUniversity of LuebeckRan2022 to 2030Enrolled114ConditionsPremature Ovarian Insufficiency, Infertility, Female, Sterility, Female, PRPArmsautologous PRP (platelet rich plasma), Saline solution (NaCL) Injection
NCT06773572 nacompletednot on this mapstarted 2024, after this paper: background citation

Efficacy of Autologous Exosomes vs Platelet-derived Growth Factors for Ovarian Regeneration in Women With Ovarian Insufficiency and Infertility: Observational, Prospective, Randomized, Comparative, Double-blind, Analytical, Prospective

TypeinterventionalSponsorBiotech Fertility C.A.Ran2024 to 2024Enrolled30ConditionsInfertility, Female, Reproductive Techniques, AssistedArmsAutologous Exososomes procedure obtained from the patients' own platelets., Patient group for activated platelet growth factors, the control group
NCT07085312 nacompletednot on this mapstarted 2023, after this paper: background citation

Evaluating the Efficacy of Exosome-Enriched Culture Media to Enhance In Vitro Maturation and Embryo Development in Poor Ovarian Responders Undergoing IVF: A Randomized Controlled Trial

TypeinterventionalSponsorFertiaguerrevereRan2023 to 2025Enrolled10ConditionsPoor Ovarian Response, Female Infertility of Other Origin, Oocyte ImmaturityArmsExosome-Enriched IVF Culture
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 5 syntheses or guidelines pooled it, 113 citations in OpenAlex.

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  7. Efficacy of single and double platelet-rich plasma treatment for diminished ovarian reserve.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

P MeloNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, OX3 9DU, UK. pmelo@doctors.org.uk.ORCID http://orcid.org/0000-0001-6809-6107
C NavarroFertiaguerrevere Fertility Clinic, Caracas, 1012, Venezuela.
C JonesNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, OX3 9DU, UK.
K CowardNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, OX3 9DU, UK.
L ColemanFertiaguerrevere Fertility Clinic, Caracas, 1012, Venezuela.
University of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the impact of a 3-month course of intracortical injections of autologous platelet-rich plasma (PRP) upon ovarian reserve markers versus no intervention in women with low ovarian reserve prior to undergoing assisted reproductive technology (ART).

methodsProspective controlled, non-randomized comparative study conducted in a private fertility clinic, in Venezuela. Women with abnormal ovarian reserve markers (FSH, AMH and AFC) who declined oocyte donation were allocated to one of the following groups according to patient choice: monthly intracortical ovarian PRP injections for three cycles, or no intervention. Primary outcomes were the change in FSH, AMH and AFC pre- and post-treatment. Secondary outcomes included the number of oocytes collected and fertilized, biochemical/clinical pregnancy rates and miscarriage and live birth rates.

resultsEighty-three women were included, of which 46 received PRP treatment and 37 underwent no intervention. Overall median age was 41 years (IQR 39-44). There were no demographic differences between the study groups. At the 3-month follow-up, women treated with PRP experienced a significant improvement in FSH, AMH and AFC, whereas there was no change in the control group. Furthermore, overall rates of biochemical (26.1% versus 5.4%, P = 0.02) and clinical pregnancy (23.9% versus 5.4%, P = 0.03) were higher in the PRP group, while there was no difference in the rates of first trimester miscarriage and live birth between groups.

conclusionPRP injections are effective and safe to improve markers of low ovarian reserve prior to ART, although further evidence is required to evaluate the impact of PRP on pregnancy outcomes.

Indexed as

Platelet-Rich PlasmaReproductive Techniques, AssistedAdultBirth RateBlood Transfusion, AutologousFemaleFertilization in VitroFollicle Stimulating HormoneHumansInfertility, FemaleOvarian ReserveOvulation InductionPregnancyPregnancy OutcomeVenezuelaFollicle Stimulating HormoneAssisted reproductive techniquesOvarian reservePlatelet-rich plasmaPregnancy outcome

Identifiers

PMID32030554
PMCPMC7183031
OpenAlexW3005057953

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.