Evidence map›Paper›PMID 32030529›Full record

GuidelineIntensive care medicine2020

Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children.

Scott L Weiss, Mark J Peters, Waleed Alhazzani, Michael S D Agus, Heidi R Flori, David P Inwald, Simon Nadel, Luregn J Schlapbach, Robert C Tasker, Andrew C Argent and 41 more

2 registry-linked trialsOpen access · bronzeAbstract readConsensus StatementPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Intensive care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 308 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
308citing papers in PubMed, 6 pooled it
53.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04728529 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Septic Shock Management Guided by Ultrasound: A Randomized Control Trial (SEPTICUS Trial)

TypeinterventionalSponsorSaptadi YuliartoRan2021 to 2023Enrolled340ConditionsSeptic ShockArmsUSSM protocol, ACCM protocol
NCT06478797 phase2unknown statusnot on this mapstarted 2024, after this paper: background citation

Adrenaline in Early Sepsis Resuscitation in Children- A Randomised Controlled Pilot Study in the Emergency Department (ANDES CHILD)

TypeinterventionalSponsorNATALIA LOPERA MUNERARan2024 to 2025Enrolled40ConditionsSepsisArmsFluid, Adrenalin
3 · Its place in the literature

Who cites it

308 citing papers in PubMed, 6 syntheses or guidelines pooled it, 569 citations in OpenAlex.

  1. Pooled it
  2. Guideline
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  7. Trial
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  10. Article
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  18. Resuscitation in paediatric septic shock using vitamin C and hydrocortisone (RESPOND): The RESPOND randomised controlled trial statistical analysis plan.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026
    Article
  19. Article
  20. Observational

248 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

51 authors at 20 institutions in 11 countries.

Scott L WeissChildren's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. WeissS@email.chop.edu.
Mark J PetersGreat Ormond Street Hospital for Children, London, UK.
Waleed AlhazzaniDepartment of Medicine, Division of Critical Care, McMaster University, Hamilton, ON, Canada.
Michael S D AgusDepartment of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Heidi R FloriC.S. Mott Children's Hospital, Ann Arbor, MI, USA.
David P InwaldSt. Mary's Hospital, London, UK.
Simon NadelSt. Mary's Hospital, London, UK.
Luregn J SchlapbachPaediatric Critical Care Research Group, The University of Queensland and Queensland Children's Hospital, Brisbane, QLD, Australia.
Robert C TaskerDepartment of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Andrew C ArgentRed Cross War Memorial Children's Hospital and University of Cape Town, Cape Town, South Africa.
Joe BrierleyGreat Ormond Street Hospital for Children, London, UK.
Joseph CarcilloChildren's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Enitan D CarrolUniversity of Liverpool, Liverpool, UK.
Christopher L CarrollConnecticut Children's Medical Center, Hartford, CT, USA.
Ira M CheifetzDuke Children's, Durham, NC, USA.
Karen ChoongDepartment of Medicine, Division of Critical Care, McMaster University, Hamilton, ON, Canada.
Jeffry J CiesSt. Christopher's Hospital for Children, Philadelphia, PA, USA.
Andrea T CruzTexas Children's Hospital, Houston, TX, USA.
Daniele De LucaParis South University Hospitals-Assistance Publique Hopitaux de Paris, Paris, France.
Akash DeepKing's College Hospital, London, UK.
Saul N FaustUniversity Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK.
Claudio Flauzino De OliveiraThe Latin America Sepsis Institute, São Paulo, Brazil.
Mark W HallNationwide Children's Hospital, Columbus, OH, USA.
Paul IshimineRady Children's Hospital, San Diego, CA, USA.
Etienne JavouheyCentre Hospitalier Universitaire de Lyon, Lyon, France.
Koen F M JoostenErasmus University Medical Center, Rotterdam, The Netherlands.
Poonam JoshiAll India Institute of Medical Sciences, New Delhi, India.
Oliver KaramChildren's Hospital of Richmond at VCU, Richmond, VA, USA.
Martin C J KneyberBeatrix Children's Hospital, Groningen, The Netherlands.
Joris LemsonRadboud University Medical Centre, Nijmegen, The Netherlands.
Graeme MacLarenNational University Health System, Singapore, Singapore.
Nilesh M MehtaDepartment of Anesthesiology, Critical Care and Pain, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Morten Hylander MøllerRigshospitalet Hospital, Copenhagen, Denmark.
Christopher J L NewthChildren's Hospital of Los Angeles, Los Angeles, CA, USA.
Trung C NguyenTexas Children's Hospital, Houston, TX, USA.
Akira NishisakiChildren's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Mark E NunnallyNew York University Langone Medical Center, New York, NY, USA.
Margaret M ParkerStony Brook University, Stony Brook, NY, USA.
Raina M PaulAdvocate Children's Hospital, Park Ridge, IL, USA.
Adrienne G RandolphDepartment of Anesthesiology, Critical Care and Pain, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Suchitra RanjitApollo Hospitals, Chennai, India.
Lewis H RomerJohns Hopkins Children's Center, Baltimore, MD, USA.
Halden F ScottChildren's Hospital Colorado, Aurora, CO, USA.
Lyvonne N TumeUniversity of the West of England, Bristol, UK.
Judy T VergerChildren's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Eric A WilliamsTexas Children's Hospital, Houston, TX, USA.
Joshua WolfSt. Jude Children's Research Hospital, Memphis, TN, USA.
Hector R WongCincinnati Children's Hospital, Cincinnati, OH, USA.
Jerry J ZimmermanSeattle Children's Hospital, Seattle, WA, USA.
Niranjan KissoonBritish Columbia Children's Hospital, Vancouver, BC, Canada.
Pierre TissieresParis South University Hospitals-Assistance Publique Hopitaux de Paris, Paris, France.
Texas Children's Hospital · USBoston Children's Hospital · USGreat Ormond Street Hospital · GBHarvard University · USMcMaster University · CASt. Mary's Hospital · GBAdvocate Children's Hospital · USAll India Institute of Medical Sciences · INApollo Hospitals · INAssistance Publique – Hôpitaux de Paris · FRBC Children's Hospital · CABeatrix Kinderziekenhuis · NLCentre National de la Recherche Scientifique · FRChildren's Hospital Colorado · USChildren's Hospital of Los Angeles · USChildren's Hospital of Philadelphia · USChildren's Hospital of Pittsburgh · USChildren's Hospital of Richmond at VCU · USCincinnati Children's Hospital Medical Center · USConnecticut Children's Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo develop evidence-based recommendations for clinicians caring for children (including infants, school-aged children, and adolescents) with septic shock and other sepsis-associated organ dysfunction.

designA panel of 49 international experts, representing 12 international organizations, as well as three methodologists and three public members was convened. Panel members assembled at key international meetings (for those panel members attending the conference), and a stand-alone meeting was held for all panel members in November 2018. A formal conflict-of-interest policy was developed at the onset of the process and enforced throughout. Teleconferences and electronic-based discussion among the chairs, co-chairs, methodologists, and group heads, as well as within subgroups, served as an integral part of the guideline development process.

methodsThe panel consisted of six subgroups: recognition and management of infection, hemodynamics and resuscitation, ventilation, endocrine and metabolic therapies, adjunctive therapies, and research priorities. We conducted a systematic review for each Population, Intervention, Control, and Outcomes question to identify the best available evidence, statistically summarized the evidence, and then assessed the quality of evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach. We used the evidence-to-decision framework to formulate recommendations as strong or weak, or as a best practice statement. In addition, "in our practice" statements were included when evidence was inconclusive to issue a recommendation, but the panel felt that some guidance based on practice patterns may be appropriate.

resultsThe panel provided 77 statements on the management and resuscitation of children with septic shock and other sepsis-associated organ dysfunction. Overall, six were strong recommendations, 49 were weak recommendations, and nine were best-practice statements. For 13 questions, no recommendations could be made; but, for 10 of these, "in our practice" statements were provided. In addition, 52 research priorities were identified.

conclusionsA large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence resulting in the frequent issuance of weak recommendations. Despite this challenge, these recommendations regarding the management of children with septic shock and other sepsis-associated organ dysfunction provide a foundation for consistent care to improve outcomes and inform future research.

Indexed as

Guidelines as TopicPediatricsSepsisAdolescentChildChild, PreschoolConsensusCritical CareHumansInfantOrgan Dysfunction ScoresEvidence-based medicineGrading of Recommendations Assessment, Development and Evaluation criteriaGuidelinesInfectionPediatricsSepsisSeptic shockSurviving Sepsis Campaign

Identifiers

PMID32030529
PMCPMC7095013
OpenAlexW3005429114

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.