ArticleEuropean journal of nuclear medicine and molecular imaging2020
Role of FDG-PET/CT in children with fever of unknown origin.
Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 61 citations in OpenAlex.
- Utility of FDG PET/CT for detection of infective endocarditis in pediatric and young adult congenital heart disease.European journal of nuclear medicine and molecular imaging · 2026Article
- Diagnostic value of basic and extended procedures in pediatric fever of unknown origin - results of a nation-wide surveillance study.Molecular and cellular pediatrics · 2026Article
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- FDG-PET/MR in paediatric pyrexia of unknown origin: early detection of Takayasu arteritis-a single-centre experience.Frontiers in pediatrics · 2026Article
- Development and validation ofQuantitative imaging in medicine and surgery · 2025Article
- FJournal of clinical medicine · 2025Article
- EANM consensus document on the use of [European journal of nuclear medicine and molecular imaging · 2024Article
- [American journal of nuclear medicine and molecular imaging · 2024Review
- Diagnostic efficacy and necessity of 18F-FDG PET/CT in fever of unknown origin: insights from a retrospective cohort study.Frontiers in medicine · 2024Article
- Update on Fever of Unknown Origin in Children: Focus on Etiologies and Clinical Approach.Children (Basel, Switzerland) · 2023Review
- SPECT/CT, PET/CT and PET/MRI: oncologic and infectious applications and protocol considerations.Pediatric radiology · 2023Review
- Imaging of pediatric hematopoietic stem cell transplant recipients: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper.Pediatric blood & cancer · 2023Article
- Advanced Imaging for Detection of Foci of Infection in Staphylococcus aureus Bacteremia- Can a Scan Save Lives?Seminars in nuclear medicine · 2023Review
- Predictors for spontaneous resolution of classical FUO in patients undergoing PET-CT.Internal and emergency medicine · 2023Article
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- Expert opinions in nuclear medicine: Finding the "holy grail" in infection imaging.Frontiers in medicine · 2023Article
- Evaluating diagnostic tests when a gold standard is not available: reply to Lo and Lo.Pediatric radiology · 2022Article
- Value ofPediatric radiology · 2022Article
- Optimal use of the FDG-PET/CT in the diagnostic process of fever of unknown origin (FUO): a comprehensive review.Japanese journal of radiology · 2022Review
- Systemic Juvenile Idiopathic Arthritis in two children; case report on clinical course, challenges in diagnosis and the role of FDG-PET/CT-scan.Clinical case reports · 2022Article
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7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine the role of
methodsThis retrospective single-center study included 110 children (0-18 years) with FUO who underwent FDG-PET/CT between 2010 and 2019. The diagnostic value of FDG-PET/CT for identifying cause of fever was calculated, treatment modifications after FDG-PET/CT were assessed, and logistic regression analyses were performed to identify clinical and biochemical factors associated with FDG-PET/CT outcome.
resultsIn 53 out of 110 patients (48%), FDG-PET/CT identified a (true positive) cause of fever. Endocarditis (11%), systemic juvenile idiopathic arthritis (5%), and inflammatory bowel disorder (5%) were the most common causes of FUO. In 42 patients (38%), no cause of fever was found on FDG-PET/CT. In 58 out of 110 patients (53%), treatment modifications were made after FDG-PET/CT. FDG-PET/CT achieved a sensitivity of 85.5%, specificity of 79.2%, positive predictive value of 84.1%, and negative predictive value of 80.9%. On multivariate logistic regression, C-reactive protein was positively associated with finding a true positive focus of fever on FDG-PET/CT (OR = 1.01 (95% CI 1.00-1.02) per mg/L increase in CRP), while leukocyte count was negatively associated with finding a true positive focus of fever (OR = 0.91 (95% CI 0.85-0.97) per 10
conclusionFDG-PET/CT is a valuable diagnostic tool in the evaluation of children with FUO, since it may detect a true underlying cause in almost half (48%) of all cases where none was found otherwise. It allows full-body evaluation in patients without disease-specific symptoms on one examination. CRP and leukocyte count were significantly associated with FDG-PET/CT results, which may contribute to a priori assessment on the outcome of FDG-PET/CT. Future research could be aimed at evaluating more patient-specific factors to prospectively estimate the added value of FDG-PET/CT in children with FUO.
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