ArticleJournal of thoracic disease2019
Extended resections for the treatment of patients with T4 stage IIIA non-small cell lung cancer (NSCLC) (T
Article in Journal of thoracic disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 14 citations in OpenAlex.
- Not All T4 Patients Should Be Considered Equal: Non-Small Cell Lung Cancer Heterogeneity and Surgical Outcome.Annals of thoracic surgery short reports · 2026Article
- Resection and reconstruction of the left atrium with cardiopulmonary bypass for T4 non-small cell lung cancer.JTCVS techniques · 2025Article
- Is extended resection for locally advanced thoracic cancer with cardiopulmonary bypass justified?BMC surgery · 2024Article
- Efficacy and safety of anlotinib in patients with advanced non-small cell lung cancer.Journal of thoracic disease · 2020Article
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8 authors at 3 institutions in 2 countries.
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Abstract
backgroundStage IIIA non-small cell lung cancer (NSCLC) is a heterogeneous group of patients, often requiring variable and individualized approaches. The dilemma to operate or not frequently arises, since more than 75% of the cases of NSCLC are diagnosed in advanced stages (IIIA). The main objective of this study was to assess whether the benefits outweigh surgical risks for the T
methodsData from 857 patients with locally advanced T4 NSCLC were retrospectively collected from two different institutions, between 2002 and 2017. Clinical data that were retrieved and analyzed, included demographics, comorbidities, surgical details, neoadjuvant or/and adjuvant therapy and postoperative complications.
resultsTwelve patients were in the cardiopulmonary bypass (CPB) group and thirty in the non-CPB. The most common types of lung cancer were squamous cell carcinoma (50.0%) and adenocarcinoma (35.7%). The most frequent invasion of the tumor was seen in main pulmonary artery and the superior vena cava. Significantly more patients of the CPB group underwent pneumonectomy as their primary lung resection (P=0.006). In all patients R0 resection was achieved according to histological reports. The overall 5-year survival was 60%, while the median overall survival was 22.5 months. Analysis revealed that patient age (P=0.027), preoperative chronic obstructive pulmonary disease (COPD) (P=0.001), tumor size (4.0
conclusionsWe suggest that in patients with stage IIIA/T4 NSCLC, complete resection of the T4 tumor, although challenging, can be performed in highly selected patients. Such an approach seems to result in improved long-term survival. More specific studies on this area of NSCLC probably will further enlighten this field, and may result in even better outcomes, as advanced systemic perioperative approaches such as modern chemotherapy, immunotherapy and improvements in radiation therapy have been incorporated in daily practice.
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