Evidence map›Paper›PMID 32030249›Full record

ArticleJournal of thoracic disease2019

Effect of normal saline flush injection into a bronchus on lung decellularization.

Masahiro Yanagiya, Kentaro Kitano, Takuma Yotsumoto, Daiya Takai, Hiromichi Asahina, Kazuhiro Nagayama, Jun Nakajima

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Masahiro YanagiyaDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Kentaro KitanoDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Takuma YotsumotoDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Daiya TakaiDepartment of Clinical Laboratory, The University of Tokyo, Tokyo, Japan.
Hiromichi AsahinaDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Kazuhiro NagayamaDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Jun NakajimaDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
The University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to evaluate effect of normal saline flush injection into bronchus on creation of decellularized lung scaffolds.

methodsPigs were used: 3 lung grafts for decellularization with pre-treatment of normal saline injection into a bronchus, 3 for decellularization without pre-treatment and 3 treated as normal controls. We compared the characteristics of lung scaffolds created by each method.

resultsThe pretreatment procedure significantly reduced the DNA content of lung grafts, suggesting effective removal of cellular components. However, this pretreatment also reduced the elastin contents of lung grafts.

conclusionsConsidering this characteristic of saline pretreatment, we must continue to look for better methods to produce ideal decellularized lung grafts.

Indexed as

decellularizationextracellular matrixlung tissue engineeringRegenerative medicine

Identifiers

PMID32030249
PMCPMC6988010
OpenAlexW2994868535

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.