Evidence map›Paper›PMID 32030203›Full record

ArticleStroke and vascular neurology2019

Sex-specific differences in white matter microvascular integrity after ischaemic stroke.

Mark R Etherton, Ona Wu, Pedro Cougo, Svetlana Lorenzano, Hua Li, Lisa Cloonan, Mark J R J Bouts, Arne Lauer, Ken Arai, Eng H Lo and 3 more

Abstract readComparative Study
In one paragraph

Article in Stroke and vascular neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Clinical characteristics and risk factors for bilateral lateral geniculate body pathology: a systematic review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Pooled it
  2. Sex and gender differences in cognitive resilience to aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  3. Article
  4. Preconditioning with interleukin-1 alpha is required for the neuroprotective properties of mesenchymal stem cells after ischemic stroke in mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  5. Article
  6. Casein Kinase 2 Signaling in White Matter Stroke.Frontiers in molecular biosciences · 2022
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mark R EthertonDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-4739-2449
Ona WuDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Pedro CougoDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Svetlana LorenzanoDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Hua LiDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Lisa CloonanDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Mark J R J BoutsDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Arne LauerDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Ken AraiDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Eng H LoDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Steve K FeskeDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Karen L FurieDepartment of Neurology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Natalia S RostDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Funding

Specialized Programs of Translational Research in Acute Stroke at the PartnersP50NS051343 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI GREENBERG, STEVEN M · 2006 to 2013
$17.5M
MRI-GENetics Interface Exploration_MRI-GENIE_StudyR01NS086905 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ROST, NATALIA S · 2015 to 2019
$3.3M
Statins augment small vessel function and improve stroke outcomesR01NS082285 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ROST, NATALIA S · 2013 to 2017
$2.6M
Quantitative MRI-based metrics for multi-center stroke treatment assessmentR01NS059775 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WU, ONA · 2008 to 2012
$2.0M
Sharing canonical human stroke dataR01NS063925 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WU, ONA · 2009 to 2010
$1.4M
NINDS NIH HHS P50 NS051343NINDS NIH HHS R01 NS059775NINDS NIH HHS R01 NS063925NINDS NIH HHS R01 NS082285NINDS NIH HHS R01 NS086905
6 · The paper itself

Abstract

Background and purpose: Functional outcomes after ischaemic stroke are worse in women, despite adjusting for differences in comorbidities and treatment approaches. White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke. The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke. Methods: A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted (DWI) and dynamic-susceptibility contrast-enhanced (DSC) perfusion-weighted imaging obtained within 9 hours of last known well was performed. In the hemisphere contralateral to the acute infarct, normal-appearing white matter (NAWM) microvascular integrity was measured using the Results: 105 men and 79 women met inclusion criteria for analysis. Despite no difference in age, women had increased NAWM Conclusions: In women with acute ischaemic stroke, increased NAWM

Indexed as

Cerebrovascular CirculationDiffusion Magnetic Resonance ImagingMicrocirculationPerfusion ImagingAgedAged, 80 and overFemaleHumansIschemic StrokeMaleMicrovesselsMiddle AgedPredictive Value of TestsPrognosisRetrospective StudiesRisk AssessmentleukoaraiosisMRIstroke

Identifiers

PMID32030203
PMCPMC6979874

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.